Redman, J.E., Ladame, S., Reszka, A.P., Neidle, S. and Balasubramanian, S. (2006) Discovery of G-quadruplex stabilising ligands through direct ELISA of a one-bead-compound library. Organic and Biomolecular Chemistry, 4 . pp. 4364-4369. 10.1039/b611716c.
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Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library James E. Redman, Sylvain Ladame, Anthony P. Reszka, Stephen Neidle and Shankar Balasubramanian We describe the identification of small-molecule G-quadruplex ligands using a direct ELISA screen of a one-bead-one-compound library of unnatural polyamides displayed on a branched linker with a biotin tag. This general purpose parallel screen for small molecule–oligonucleotide interactions was validated by surface plasmon resonance and ELISA of resynthesized compounds. Linear polyamides displayed similar rankings in their affinity for quadruplex as their branched counterparts. Quadruplex affinity as judged by these surface based techniques was a useful predictor of the ability of the ligands to stabilize the quadruplex to thermal unfolding in solution. Graphical abstract image for this article (ID: b611716c)
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Cancer Research UK Biomolecular Structure Group|
|Journal or Publication Title:||Organic and Biomolecular Chemistry|
|Deposited By:||Library Staff|
|Deposited On:||21 Jun 2007|
|Last Modified:||19 Sep 2007 11:16|
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