NMDA receptor surface trafficking depends on NR2A/NR2B subunits

Groc, L., Heine, M., Cousins, S.L., Stephenson, F.A., Lounis, B., Cognet, L. and Choquet, D. (2006) NMDA receptor surface trafficking depends on NR2A/NR2B subunits. Proceedings of the National Academy of Sciences of the USA, 103 (49). pp. 18769-18774. 10.1073/pnas.0605238103.

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DOI: 10.1073/pnas.0605238103

Abstract

The NR2 subunit composition of NMDA receptors (NMDARs) varies during development, and this change is important in NMDAR-dependent signaling. In particular, synaptic NMDAR switch from containing mostly NR2B subunit to a mixture of NR2B and NR2A subunits. The pathways by which neurons differentially traffic NR2A- and NR2B-containing NMDARs are poorly understood. Using single-particle and -molecule approaches and specific antibodies directed against NR2A and NR2B extracellular epitopes, we investigated the surface mobility of native NR2A and NR2B subunits at the surface of cultured neurons. The surface mobility of NMDARs depends on the NR2 subunit subtype, with NR2A-containing NMDARs being more stable than NR2B-containing ones, and NR2A subunit overexpression stabilizes surface NR2B-containing NMDARs. The developmental change in the synaptic surface content of NR2A and NR2B subunits was correlated with a developmental change in the time spent by the subunits within synapses. This suggests that the switch in synaptic NMDAR subtypes depends on the regulation of the receptor surface trafficking.

Item Type:Article
Additional Information:Full text available electronically and in print from the School of Pharmacy Library.
Uncontrolled Keywords:development glutamate receptor lateral mobility
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:826
Journal or Publication Title:Proceedings of the National Academy of Sciences of the USA
Deposited By:Library Staff
Deposited On:22 Oct 2007 13:33
Last Modified:24 Nov 2011 14:21

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