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Article

Parkinson, G.N., Lee, M.P.H. and Neidle, S. (2002) Crystal structure of parallel quadruplexes from human telomeric DNA. Nature, 417 (6891). pp. 876-880. 10.1038/nature755.

Haider, S.M., Parkinson, G.N. and Neidle, S. (2003) Structure of a G-quadruplex–Ligand Complex. Journal of Molecular Biology, 326 (1). pp. 117-125. 10.1016/S0022-2836(02)01354-2.

Clark, G.R., Pytel, P.D., Squire, C.J. and Neidle, S. (2003) Structure of the first parallel DNA quadruplex-drug complex. Journal of the American Chemical Society, 125 (9). pp. 4066-4067. 10.1021/ja0297988.

Joubert, A., Sun, X.W., Johansson, E., Bailly, C., Mann, J. and Neidle, S. (2003) Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole. Biochemistry, 42 (20). pp. 5984-5992. 10.1021/bi026926w.

Parkinson, G.N. and Neidle, S. (2003) The structure of telomeric DNA. Current Opinion in Structural Biology, 13 (3). pp. 275-283. 10.1016/S0959-440X(03)00072-1.

Johansson, E., Parkinson, G.N., Denny, W.A. and Neidle, S. (2003) Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the nhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. Journal of Medicinal Chemistry, 46 (19). pp. 4009-4020. 10.1021/jm030843b.

Harrison, R.J., Cuesta, J., Chessari, G., Read, M.A., Basra, S.K., Reszka, A.P., Morrell, J., Gowan, S.M., Incles, C.M., Tanious, F.A., Wilson, W.D., Kelland, L.R. and Neidle, S. (2003) Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. Journal of Medicinal Chemistry, 46 (21). pp. 4463-4476. 10.1021/jm0308693.

Incles, C.M., Schultes, C.M., Kelland, L.R. and Neidle, S. (2003) Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor. Molecular Pharmacology, 64 (5). pp. 1101-1108. 10.1124/mol.64.5.1101.

Seaton, A., Higgins, C., Mann, J., Bailly, C., Neidle, S. and van den Berg, H. (2003) Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles. European Journal of Cancer, 39 (17). pp. 2548-2555. 10.1016/S0959-8049(03)00621-X .

Nguyen, B., Hamelberg, D., Bailly, C., Colson, P., Stanek, J., Brun, R., Neidle, S. and Wilson, W.D. (2004) Characterization of a novel DNA minor-groove complex. Biophysical Journal, 86 (2). pp. 1028-1041. PMC1303896.

Guyen, B., Schultes, C.M., Hazel, P., Mann, J. and Neidle, S. (2004) Synthesis and evaluation of analogues of 10H-indolo[3,2-b] quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Organic and Biomolecular Chemistry, 2 (7). pp. 981-989. 10.1039/B316055F .

Schultes, C.M., Guyen, B., Cuesta, J. and Neidle, S. (2004) Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors. Bioorganic and Medicinal Chemistry Letters, 14 (16). pp. 4347-4351. 10.1016/j.bmcl.2004.05.090 .

Ladame, S., Schouten, J.A., Stuart, J., Roldan, J., Neidle, S. and Balasubramanian, S. (2004) Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. Organic and Biomolecular Chemistry, 2 (20). pp. 2925-2931. 10.1039/B409698C .

Mallena, S., Lee, M.P., Bailly, C., Neidle, S., Kumar, A., Boykin, D.W. and Wilson, W.D. (2004) Thiophene-based diamidine forms a "super" at binding minor groove agent. Journal of the American Chemical Society, 126 (42). pp. 13659-136569. 10.1021/ja048175m.

Harrison, R.J., Reszka, A.P., Haider, S.M., Romagnoli, B., Morrell, J., Read, M.A., Gowan, S.M., Incles, C.M., Kelland, L.R. and Neidle, S. (2004) Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorganic and Medicinal Chemistry Letters, 14 (23). pp. 5845-5849. 10.1016/j.bmcl.2004.09.037.

Hazel, P., Huppert, J., Balasubramanian, S. and Neidle, S. (2004) Loop-length-dependent folding of G-quadruplexes. Journal of the American Chemical Society, 126 (50). pp. 16405-16415. 10.1021/ja045154j.

Burger, A.M., Dai, F., Schultes, C.M., Reszka, A.P., Moore, M.J.B., Double, J.A. and Neidle, S. (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Research, 65 (4). pp. 1489-1496. 10.1158/0008-5472.CAN-04-2910 .

Neidle, S. and Thurston, D.E. (2005) The role of chemical sciences in 21st century cancer drug discovery. Discovery Medicine, 5 (29). pp. 450-454.

Miao, Y., Lee, M.P., Parkinson, G.N., Batista-Parra, A., Ismail, M.A., Neidle, S., Boykin, D.W. and Wilson, W.D. (2005) Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry, 44 (45). pp. 14701-14708. 10.1016/j.bpc.2006.06.006.

Redman, J.E., Ladame, S., Reszka, A.P., Neidle, S. and Balasubramanian, S. (2006) Discovery of G-quadruplex stabilising ligands through direct ELISA of a one-bead-compound library. Organic and Biomolecular Chemistry, 4 . pp. 4364-4369. 10.1039/b611716c.

Le Sann, C., Baron, A., Mann, J., van den Berg, H., Gunaratnam, M. and Neidle, S. (2006) New mustard-linked 2-aryl-bis-benzimadazoles with anti-proliferative activity. Organic and Biomolecular Chemistry, 4 . pp. 1305-1312. 10.1039/b600567e.

Moorhouse, A.D., Santos, A.M., Gunaratnam, M., Moore, M.J.B., Neidle, S. and Moses, J.E. (2006) Stabilisation of G-quadruplex DNA by highly specific ligands via click chemistry. Journal of the American Chemical Society, 128 (50). pp. 15972-15973. 10.1021/ja0661919.

Reed, J.E., Arnal, Anna Arola, Neidle, S. and Vilar, R. (2006) Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. Journal of the American Chemical Society, 128 . pp. 5992-5993. 10.1021/ja058509n.

Campbell, N.H., Evans, D.H., Lee, M.P.H., Parkinson, G.N. and Neidle, S. (2006) Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure. Bioorganic and Medicinal Chemistry Letters, 16 (1). pp. 15-19. 10.1016/j.bmcl.2005.10.036.

Hazel, P., Parkinson, G.N. and Neidle, S. (2006) Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. Journal of the American Chemical Society, 128 . pp. 5480-5487. 10.1021/ja058577+.

Moore, M.J.B., Schultes, C.M., Cuesta, J., Cuenca, F., Gunaratnam, M., Tanious, F.A., Wilson, W.D. and Neidle, S. (2006) Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3, 6- and 9-side chains on quadruplex binding, telomerase activity and cell proliferation. Journal of Medicinal Chemistry, 49 . pp. 582-599. 10.1021/jm050555a.

Ladame, S., Schouten, J.A., Roldan, J., Redman, J.E., Neidle, S. and Balasubramanian, S. (2006) Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry, 45 (5). pp. 1393-1399. 10.1021/bi050229x.

Hazel, P., Parkinson, G.N. and Neidle, S. (2006) Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Research, 34 (7). pp. 2117-2127. 10.1093/nar/gkl182 .

Fernando, Himesh, Reszka, A.P., Huppert, J., Ladame, S., Rankin, S., Venkitaraman, Ashok R., Neidle, S. and Balasubramanian, S. (2006) A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry, 45 . pp. 7854-7860. 10.1021/bi0601510.

Moore, M.J.B., Cuenca, F., Searcey, M. and Neidle, S. (2006) Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Organic and Biomolecular Chemistry, 4 . pp. 3479-3488. 10.1039/b607707b.

Evans, David A. and Neidle, S. (2006) Virtual screening of DNA minor groove binders. Journal of Medicinal Chemistry, 49 . pp. 4232-4238. 10.1021/jm0601957.

Burge, Sarah, Parkinson, G.N., Hazel, P., Todd, A.K. and Neidle, S. (2006) Quadruplex DNA: sequence, topology and structure. Nucleic Acids Research, 34 (19). pp. 5402-5415. 10.1093/nar/gkl655.

Milroy, L.G., Zinzalla, G., Prencipe, G., Michel, P., Ley, S.V., Gunaratnam, M., Beltran, M. and Neidle, S. (2007) Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. Angewandte Chemie, 46 (14). pp. 2493-2496. 10.1002/anie.200604688.

Todd, A.K., Haider, S.M., Parkinson, G.N. and Neidle, S. (2007) Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Research, 35 (17). pp. 5799-5808. 10.1093/nar/gkm609.

White, E.W., Tanious, F.A., Ismail, M.A., Reszka, A.P., Neidle, S., Boykin, D.W. and Wilson, W.D. (2007) Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophysical Chemistry, 126 (1-3). pp. 140-153. 10.1016/j.bpc.2006.06.006.

Parkinson, G.N., Ghosh, R. and Neidle, S. (2007) Structural basis for binding of porphyrin to human telomeres. Biochemistry, 46 (9). pp. 2390-2397. 10.1021/bi062244n.

Davies, R.J., Malone, J.F., Gan, Y., Cardin, C.J., Lee, M.P. and Neidle, S. (2007) High-resolution crystal structure of the intramolecular d(TpA) thymine-adenine photoadduct and its mechanistic implications. Nucleic Acids Research, 35 (4). pp. 1048-1053. 10.1093/nar/gkl1101..

Phan, A.T., Kuryavyi, V., Burge, S., Neidle, S. and Patel, D.J. (2007) Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. Journal of the American Chemical Society, 129 (14). pp. 4386-4392. 10.1021/ja068739h.

Martins, C., Gunaratnam, M., Stuart, J., Makwana, V., Greciano, O., Reszka, A.P., Kelland, L.R. and Neidle, S. (2007) Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorganic and Medicinal Chemistry Letters, 17 (8). pp. 2293-2298. 10.1016/j.bmcl.2007.01.056.

Lee, M.P., Parkinson, G.N., Hazel, P. and Neidle, S. (2007) Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. Journal of the American Chemical Society, 129 (33). pp. 10106-10107. 10.1021/ja0740869.

Drewe, W.C. and Neidle, S. (2008) Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers. Chemical Communications (42). pp. 5295-5297. 10.1039/b817545b.

Arola-Arnal, A., Benet, J., Neidle, S. and Vilar, R. (2008) Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorganic Chemistry, 47 . pp. 11910-11919. 10.1021/ic8016547.

Campbell, N.H., Parkinson, G.N., Reszka, A.P. and Neidle, S. (2008) Structural basis of DNA quadruplex recognition by an acridine drug. Journal of the American Chemical Society, 130 (21). pp. 6722-6724. 10.1021/ja8016973.

Moorhouse, A.D., Gunaratnam, M., Haider, S.M., Munnur, D., Neidle, S. and Moses, J.E. (2008) Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Molecular Biosystems, 4 (6). pp. 629-642. 10.1039/b801822g.

Parkinson, G.N., Cuenca, F. and Neidle, S. (2008) Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. Journal of Molecular Biology, 381 (5). pp. 1145-1156. 10.1016/j.jmb.2008.06.022.

Reed, J.E., Gunaratnam, M., Beltran, M., Reszka, A.P., Vilar, R. and Neidle, S. (2008) TRAP-LIG, a modified TRAP assay to quantitate telomerase inhibition by small molecules. Analytical Biochemistry, 380 . pp. 99-105. 10.1016/j.ab.2008.05.013.

Zagotto, G., Sissi, C., Moro, S., Del Ben, D., Parkinson, G.N., Fox, S., Neidle, S. and Palumbo, M. (2008) Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorganic & Medicinal Chemistry, 16 (1). pp. 354-361. 10.1016/j.bmc.2007.09.040.

Cuenca, F., Greciano, O., Gunaratnam, M., Haider, S.M., Munnur, D., Nanjunda, R., Wilson, W.D. and Neidle, S. (2008) Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorganic and Medicinal Chemistry Letters, 18 (5). pp. 1668-1673. 10.1016/j.bmcl.2008.01.050.

Todd, A.K. and Neidle, S. (2008) The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Research, 36 (8). pp. 2700-2704. 10.1093/nar/gkn078.

Haider, S.M., Parkinson, G.N. and Neidle, S. (2008) Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophysical Journal, 95 (1). pp. 296-311. 10.1529/biophysj.107.120501.

Neidle, S. and Parkinson, G.N. (2008) Quadruplex DNA crystal structures and drug design. Biochimie, 90 (8). pp. 1184-1190. 10.1016/j.biochi.2008.03.003.

Zagotto, G., Sissi, C., Lucatello, L., Pivetta, C., Cadamuro, S.A., Fox, K.R., Neidle, S. and Palumbo, M. (2008) Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. Journal of Medicinal Chemistry, 51 (18). pp. 5566-5574. 10.1021/jm800160v.

Drewe, W.C., Nanjunda, R., Gunaratnam, M., Beltran, M., Parkinson, G.N., Reszka, A.P., Wilson, W.D. and Neidle, S. (2008) Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. Journal of Medicinal Chemistry, 51 (24). pp. 7751-7767. 10.1021/jm801245v.

Hsu, S.T.D., Varnai, P., Reszka, A.P., Neidle, S. and Balasubramanian, S. (2009) A G-rich sequence with the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. Journal of the American Chemical Society, 131 (37). pp. 13399-13409. 10.1021/ja904007p.

Rahman, K.M., Reszka, A.P., Gunaratnam, M., Haider, S.M., Howard, P.W., Fox, K.R., Neidle, S. and Thurston, D.E. (2009) Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Chemical Communications, 27 . pp. 4097-4099. 10.1039/b902359c.

Gibbons, S., O'Donnell, G., Poeschl, R., Zimhony, O., Gunaratnam, M., Moreira, J.B., Neidle, S., Evangelopoulos, D., Bhakta, S., Malkinson, J.P., Boshoff, H. and Lenaerts, A. (2009) Bioactive pyridine-N-oxide disulphides from Allium stipitatum. Journal of Natural Products, 72 (3). pp. 360-365. 10.1021/np800572r.

Cuenca, F., Moore, M.J.B., Johnson, K., Guyen, B., De Cian, A. and Neidle, S. (2009) Design, synthesis and evaluation of 4,5-disubstituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells. Bioorganic and Medicinal Chemistry Letters, 19 (17). pp. 5109-5113. 10.1016/j.bmcl.2009.07.033 .

Reed, J.E., White, A.J.P., Neidle, S. and Vilar, R. (2009) Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA. Journal of the Chemical Society, Dalton Transactions (14). pp. 2558-2568. 10.1039/b820086f.

Tai, K., Haider, S.M., Grottesi, A. and Sansom, M.S.P. (2009) Ion channel gates: comparative analysis of energy barriers. European Biophysics Journal, 38 (4). pp. 347-354. doi:10.1007/s00249-008-0377-x.

Redman, J.E., Granadino-Roldan, J.M., Schouten, J.A., Ladame, S., Reszka, A.P., Neidle, S. and Balasubramanian, S. (2009) Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Organic and Biomolecular Chemistry, 7 . pp. 76-84. 10.1039/b814682a.

Campbell, N.H., Patel, M., Tofa, A., Ghosh, R., Parkinson, G.N. and Neidle, S. (2009) Selectivity in ligand recognition of G-quadruplex loops. Biochemistry, 48 (1). pp. 1675-1680. 10.1021/bi802233v.

Collie, G.W., Reszka, A.P., Haider, S.M., Gabelica, V., Parkinson, G.N. and Neidle, S. (2009) Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chemical Communications, 48 . pp. 7482-7484. 10.1039/b901889a.

Martino, L., Pagano, B., Fotticchia, I., Neidle, S. and Giancola, C. (2009) Shedding light on the interaction of TMPyP4 with human telomeric quadruplexes. Journal of Physical Chemistry B, 113 (44). pp. 14779-14786. 10.1021/jp9066394.

Gunaratnam, M., Swank, S., Haider, S.M., Galesa, K., Reszka, A.P., Beltran, M., Cuenca, F., Fletcher, J.A. and Neidle, S. (2009) Targeting human gastrointestinal stromal tumour cells with a quadruplex-binding small molecule. Journal of Medicinal Chemistry, 52 (12). pp. 3774-3783. 10.1021/jm900424a.

Nguyen, B., Neidle, S. and Wilson, W.D. (2009) A role for water molecules in DNA−ligand minor groove recognition. Accounts of Chemical Research, 42 (1). pp. 11-21. 10.1021/ar800016q.

Haider, S.M. and Neidle, S. (2009) A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. Biochemical Society Transactions, 37 (3). pp. 583-588. 10.1042/BST0370583.

Balasubramanian, S. and Neidle, S. (2009) G-quadruplex nucleic acids as therapeutic targets. Current Opinion in Chemical Biology, 13 (3). pp. 345-353. 10.1016/j.cbpa.2009.04.637 .

Neidle, S. (2009) The structures of quadruplex nucleic acids and their drug complexes. Current Opinion in Structural Biology, 19 (3). pp. 239-250. 10.1016/j.sbi.2009.04.001 .

Gunaratnam, M., Green, C., Moreira, J.B., Moorhouse, A.D., Kelland, L.R., Moses, J.E. and Neidle, S. (2009) G-quadruplex compounds and cisplatin act synergistically to inhibit cancer cell growth in vitro and in vivo. Biochemical Pharmacology, 78 (2). pp. 115-122. 10.1016/j.bcp.2009.03.018 .

Micheli, E., Lombardo, C.M., D'Ambrosio, D., Franceschin, M., Neidle, S. and Savino, M. (2009) Selective G-quadruplex ligands: the significant role of side chain charge density in a series of perylene derivatives. Bioorganic and Medicinal Chemistry Letters, 19 (14). pp. 3903-3908. 10.1016/j.bmcl.2009.03.106.

Zinzalla, G., Haque, M.R., Basu, B Piku, Anderson, J., Kaye, S.L., Haider, S.M., Hasan, F., Antonow, D., Essex, S., Rahman, K.M., Palmer, J., Morgenstern, D., Wilderspin, A.F., Neidle, S. and Thurston, D.E. (2010) A novel small-molecule inhibitor of IL-6 signalling. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7029-32. 10.1016/j.bmcl.2010.09.117.

Sparapani, S., Bellini, S., Gunaratnam, M., Haider, S.M., Andreani, A., Rambaldi, M., Locatelli, A., Morigi, R., Granaiola, M., Varoli, L., Burnelli, S., Leoni, A. and Neidle, S. (2010) Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chemical Communications, 46 (31). pp. 5680-5682. 10.1039/c0cc00020e.

Lavrado, J., Reszka, A.P., Moreira, R., Neidle, S. and Paulo, A. (2010) C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7042-5. 10.1016/j.bmcl.2010.09.110.

Neidle, S. (2010) Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS Journal, 277 (5). pp. 1118-1125. 10.1111/j.1742-4658.2009.07463.x.

Sparapani, S., Haider, S.M., Doria, F., Gunaratnam, M. and Neidle, S. (2010) Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. Journal of the American Chemical Society, 132 (35). pp. 12263-12272. 10.1021/ja1003944.

Hampel, Sonja M, Sidibe, Assitan, Gunaratnam, M., Riou, Jean-Francois and Neidle, S. (2010) Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorganic & Medicinal Chemistry Letters, 20 (22). pp. 6459-63. 10.1016/j.bmcl.2010.09.066 .

Collie, G.W., Haider, S.M., Neidle, S. and Parkinson, G.N. (2010) A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Research . 10.1093/nar/gkq259 .

Leonard, P.G., Parkinson, G.N., Gor, J., Perkins, S.J. and Ladbury, J.E. (2010) The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein. Acta Crystallographica Section F - Structural Biology and Crystallization Communications, 66 . pp. 421-425. 10.1107/S1744309110004574.

Moses, J., Ritson, D., Zhang, F., Lombardo, C.M., Haider, S.M., Oldham, N. and Neidle, S. (2010) A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Organic and Biomolecular Chemistry, 8 (13). pp. 2926-2930. 10.1039/c005055e.

Collie, G.W., Parkinson, G.N., Neidle, S., Rosu, F., De Pauw, E. and Gabelica, V. (2010) Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. Journal of the American Chemical Society . 10.1021/ja100345z.

Haider, S.M., Patel, J., Poojari, C. and Neidle, S. (2010) Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. Journal of Molecular Biology, 400 (5). pp. 1078-1098. 10.1016/j.jmb.2010.05.069 .

Neidle, S. (2010) Methods for studying quadruplex nucleic acids. Current Opinion in Structural Biology, 43 (4). p. 245. 10.1016/j.ymeth.2007.10.001.

Campbell, N.H., Smith, D.L., Reszka, A.P., Neidle, S. and O'Hagan, D. (2011) Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Organic & biomolecular chemistry, 9 (5). pp. 1328-1331. doi:10.1039/c0ob00886a.

Collie, G.W., Sparapani, S., Parkinson, G.N. and Neidle, S. (2011) Structural basis of telomeric RNA quadruplex-acridine ligand recognition. Journal of the American Chemical Society, 133 (8). pp. 2721-2728. 10.1021/ja109767y.

Balasubramanian, S., Hurley, L.H. and Neidle, S. (2011) Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nature Reviews. Drug discovery, 10 (4). pp. 261-275. 10.1038/nrd3428.

Todd, A.K. and Neidle, S. (2011) Mapping the sequences of potential guanine quadruplex motifs. Nucleic Acids Research . 10.1093/nar/gkr104 .

Haider, S.M., Autiero, I. and Neidle, S. (2011) Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes. Biochimie, 93 (8). pp. 1275-1279. 10.1016/j.biochi.2011.05.014.

Baud, M.G.J., Leiser, T., Haus, P., Samlal, S., Wong, A.C., Wood, R.J., Petrucci, V., Gunaratnam, M., Hughes, S.M., Buluwela, L., Turlais, F., Neidle, S., Meyer-Almes, F-J., White, A.J.P. and Fuchter, M.J. (2012) Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets. Journal of Medicinal Chemistry, 55 (4). pp. 1731-1750. 10.1021/jm2016182.

Book

Neidle, S., Balasubramanian, S., Campbell, S.F., Clore, M. and Lilley, David M.J., eds. (2006) Quadruplex nucleic acids. Royal Society of Chemistry. ISBN 0854043748.

Neidle, S. (2007) Cancer Drug Design and Discovery. Academic Press. ISBN 0123694485.

Neidle, S. (2007) Principles of Nucleic Acid Structure. Academic Press. ISBN 0123695074.

Book Section

Neidle, S. (2006) The discovery of G-quadruplex telomere targeting drugs. In: Sequence-Specific DNA binding agents. Royal Society of Chemistry, pp. 190-206.

Neidle, S. (2006) Structural bioinformatics in cancer. In: Cancer Bioinformatics. John Wiley and Sons Ltd.. ISBN 0470863048.

Neidle, S., Schneider, B. and Berman, H.M. (2009) Fundamentals of DNA and RNA structure. In: Structural Bioinformatics. John Wiley & Sons Inc., pp. 41-77. ISBN 0470181052 .

Haider, S.M. and Neidle, S. (2010) Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. In: G-Quadruplex DNA: Methods and Protocols. Methods in molecular biology (608). Humana Press, NJ, USA, pp. 17-37. ISBN 978-1588299505 . 10.1007/978-1-59745-363-9_2.

Gunaratnam, M. and Neidle, S. (2010) An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells. In: Drug-DNA Interaction Protocols. Methods in molecular biology (613 ). Humana Press, NJ, USA, pp. 303-13. ISBN 978-1-60327-417-3. 10.1007/978-1-60327-418-0_19.

This list was generated on Thu Apr 24 18:27:21 2014 BST.