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Number of items: 53.

Cong, Y., Pawlisz, E., Bryant, P., Balan, S., Laurine, E., Tommasi, R., Singh, R., Dubey, S., Peciak, K., Bird, M., Sivasankar, A., Swierkosz, J., Muroni, M., Heidelberger, S., Farys, M., Khayrzad, F., Edwards, J., Badescu, G., Hodgson, I., Heise, C., Somavarapu, S., Liddell, J., Powell, K., Zloh, M., Choi, J-W., Godwin, A. and Brocchini, S. (2012) Site-Specific PEGylation at Histidine Tags. Bioconjugate Chemistry, 23 (2). pp. 248-263. 10.1021/bc200530x.

Al-Obaidi, H., Ke, P., Brocchini, S. and Buckton, G. (2011) Characterization and stability of ternary solid dispersions with PVP and PHPMA. International Journal of Pharmaceutics, 419 (1-2). p. 20. 10.1016/j.ijpharm.2011.06.052.

Barata, T.S., Brocchini, S., Teo, I., Shaunak, S. and Zloh, M. (2011) From sequence to 3D structure of hyperbranched molecules: application to surface modified PAMAM dendrimers. Journal of Molecular Modeling . 10.1007/s00894-011-0966-y.

Barata, T.S., Teo, I., Brocchini, S., Zloh, M. and Shaunak, S. (2011) Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses. PLoS computational biology, 7 (6). e1002095. 10.1371/journal.pcbi.1002095.

Barata, T.S., Shaunak, S., Teo, I., Zloh, M. and Brocchini, S. (2011) Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers. Journal of Molecular Modeling, 17 (8). pp. 2051-2060. 10.1007/s00894-010-0907-1.

Georgoulas, S., Dahlmann-Noor, A., Brocchini, S. and Khaw, P.T. (2010) Wound-healing responses to glaucoma surgery. In: Ocular Disease Mechanisms and Management. Saunders Elsevier, pp. 214-222. ISBN 978-0-7020-2983-7.

Barbosa, H.S.C., Hine, A.V., Brocchini, S., Slater, N.K.H. and Marcos, J.C. (2010) Dual affinity method for plasmid DNA purification in aqueous two-phase systems. Journal of Chromatography A, 1217 (9). pp. 1429-1436. 10.1016/j.chroma.2009.12.059 .

Brocchini,S. (2009) Derivatisation of biological molecules. EP2118150.

Brocchini,S. (2009) Conjugated biological molecules and their preparation. 7,595,292.

Brocchini,S. (2009) Preparation and uses for polyarylates. 7,585,929.

Al-Obaidi, H., Brocchini, S. and Buckton, G. (2009) Anomalous properties of spray dried solid dispersions. Journal of Pharmaceutical Sciences, 98 (12). pp. 4724-4737. doi:10.1002/jps.21782.

Brocchini,S. (2009) Novel complexes and a process for their preparation. WO09060218.

Brocchini,S. (2009) Novel conjugated proteins and peptides. WO09047500.

Choi, J-W., Godwin, A., Balan, S., Bryant, P., Cong, Y., Pawlisz, E., Porssa, M., Rumpf, N., Singh, R., Powell, K. and Brocchini, S. (2009) Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation. In: Protein PEGylation, basic science and biological applications. Milestones in Drug Therapy . Birkhauser, Basel, Switzerland, pp. 47-74. ISBN 978-3-7643-8678-8.

Barbosa, H.S.C., Hine, A.V., Brocchini, S., Slater, N.K.H. and Marcos, J.C. (2008) Affinity partitioning of plasmid DNA with a zinc finger protein. Journal of Chromatography A, 1206 (2). pp. 105-112. 10.1016/j.chroma.2008.07.095.

Brocchini, S., Godwin, A., Balan, S., Choi, J-W., Zloh, M. and Shaunak, S. (2008) Disulfide bridge based PEGylation of proteins. Advanced Drug Delivery Reviews, 60 (1). pp. 3-12. 10.1016/j.addr.2007.06.014.

Georgoulas, S., Dahlmann-Noor, A., Brocchini, S. and Khaw, P.T. (2008) Modulation of wound healing during and after glaucoma surgery. Progress in Brain Research, 173 . pp. 237-254. 10.1016/S0079-6123(08)01117-5 .

Lewis, A., Tang, Y., Brocchini, S., Choi, J-W. and Godwin, A. (2008) Poly(2-methacryloyloxyethyl phosphorylcholine) for protein conjugation. Bioconjugate Chemistry, 19 (11). pp. 2144-2155. 10.1021/bc800242t.

Fadda, H.M., Hernandez, M.C., Margetson, D.N., McAllister, S.M., Basit, A.W., Brocchini, S. and Suarez, N. (2008) The molecular interactions that influence the plasticizer dependent dissolution of acrylic polymer films. Journal of Pharmaceutical Sciences, 97 (9). pp. 3957-3971. 10.1002/jps.21292.

Zloh, M., Shaunak, S., Balan, S. and Brocchini, S. (2007) Identification and insertion of 3 carbon bridge in protein disulfide bonds. Nature Protocols, 2 (5). pp. 1070-1083. 10.1038/nprot.2007.119.

Godwin, A., Choi, J-W., Pedone, E., Shaunak, S., Brocchini, S. and Zloh, M. (2007) Molecular dynamics simulation of proteins with modified disulfide bonds. Theoretical Chemistry Accounts, 117 (2). pp. 259-263. 10.1007/s00214-006-0134-0.

Balan, S., Choi, J-W., Godwin, A., Teo, I., Laborde, C.M., Heidelberger, S., Zloh, M., Shaunak, S. and Brocchini, S. (2007) Site-specific PEGylation of protein disulfide bonds using a 3-carbon bridge. Bioconjugate Chemistry, 18 (1). pp. 61-76. 10.1021/bc0601471.

Shaunak, S., Godwin, A., Choi, J-W., Balan, S., Pedone, E., Vijayarangam, D., Heidelberger, S., Teo, I., Zloh, M. and Brocchini, S. (2006) Site-specific PEGylation of native disulfide bonds in therapeutic proteins. Nature Chemical Biology, 2 . pp. 312-313. 10.1038/nchembio786.

Shaunak, S. and Brocchini, S. (2006) Dendrimer-based drugs as macromolecular medicines. Biotechnology and Genetic Engineering Reviews, 23 . pp. 309-315.

Brocchini, S., Balan, S., Zloh, M. and Shaunak, S. (2006) Efficient PEGylation of proteins by bis-thiol alkylation of native disulfide bonds. Nature Protocols, 1 (5). pp. 2241-2252. 10.1038/nprot.2006.346.

Brocchini, S., Balan, S., Godwin, A., Choi, J-W., Zloh, M. and Shaunak, S. (2006) PEGylation of native disulfide bonds in proteins. Nature Protocols, 1 (5). pp. 2241-2252. 10.1038/nprot.2006.346.

Brocchini, S., Balan, S., Zloh, M. and Shaunak, S. (2006) PEGylation of proteins by bis-thiol alkylation of native disulfide bonds. Nature Protocols, 1 . pp. 2241-2252. 10.1038/nprot.2006.346.

Pedone, E. and Brocchini, S. (2006) Synthesis of two photolabile poly(ethylene glycol) derivatives for protein conjugation. Reactive and Functional Polymers, 66 (1). pp. 167-176.

Ali, M. and Brocchini, S. (2006) Synthetic approaches to uniform polymers☆. Advanced Drug Delivery Reviews, 58 (15). pp. 1671-1687. 10.1016/j.addr.2006.10.002.

Rickerby, J., Prabhakar, R., Patel, A.V., Knowles, J. and Brocchini, S. (2005) A biomedical library of serinol-derived polyesters. Journal of Controlled Release, 101 (1-3). pp. 21-34. 10.1016/j.jconrel.2004.07.021.

Pollitt, M.J., Buckton, G., Brocchini, S. and Alpar, H.O. (2005) Calorimetric study of bovine serum albumin dilution and adsorption onto polystyrene particles. International Journal of Pharmaceutics, 298 (2). pp. 339-343. 10.1016/j.ijpharm.2005.02.037.

Prabhakar, R., Brocchini, S. and Knowles, J. (2005) Effect of glass composition on the degradation properties and ion release characteristics of phosphate glass?polycaprolactone composites. Biomaterials, 26 (15). p. 2209.

Fletcher, J.A., Godwin, A., Pedone, E., Jahangeer, B., Buckton, G. and Brocchini, S. (2005) The use of procursor polymers to prepare new excipients. Journal of Drug Delivery Science and Technology, 15 (4). pp. 295-299.

Vicent, M.J., Tomlinson, R., Brocchini, S. and Duncan, R. (2004) Polyacetal-diethylstilboestrol: a polymeric drug designed for pH-triggered activation. Journal of Drug Targeting, 12 (8). pp. 491-501. 10.1080/10611860400011885.

Shaunak, S., Thomas, S., Gianasi, E., Godwin, A., Jones, E., Teo, I., Mireskandari, K., Luthert, P., Duncan, R., Patterson, S., Khaw, P.T. and Brocchini, S. (2004) Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nature Biotechnology, 22 (8). p. 977. 10.1038/nbt995.

Al-Hadithi, D., Buckton, G. and Brocchini, S. (2004) Quantification of amorphous content in mixed systems: amorphous trehalose with lactose. Thermochimica Acta, 417 (2). pp. 193-199. 10.1016/j.tca.2003.09.030.

Zloh, M., Dinand, E. and Brocchini, S. (2003) Aconityl-derived polymers for biomedical applications: modeling study of cis-trans isomerisation. Theoretical Chemistry Accounts, 109 . pp. 206-212. 10.1007/s00214-002-0403-5.

Pedone, E., Li, X., Koseva, N., Alpar, O. and Brocchini, S. (2003) An information rich biomedical polymer library. Basis of a presentation given at Materials Discussion No. 6, 12-14th September 2003, Durham, UK. Journal of Materials Chemistry, 13 (11). pp. 2825-2837. 10.1039/b306857a.

Tomlinson, R., Heller, J., Brocchini, S. and Duncan, R. (2003) Polyacetal−Doxorubicin Conjugates Designed for pH-Dependent Degradation. Bioconjugate Chemistry, 14 (6). pp. 1096-1106. 10.1021/bc030028a.

Brocchini, S. (2003) Polymers in medicine; a game of chess▾. Drug Discovery Today, 8 (3). pp. 111-112. 10.1016/S1359-6446(02)02583-7.

Dinand, E., Zloh, M. and Brocchini, S. (2002) Competitive reactions during amine addition to cis-aconityl anhydride. Australian Journal of Chemistry, 55 . pp. 467-474. 10.1071/CH02092.

Tomlinson, R., Klee, M., Garrett, S., Heller, J., Duncan, R. and Brocchini, S. (2002) Pendent Chain Functionalized Polyacetals That Display pH-Dependent Degradation:  A Platform for the Development of Novel Polymer Therapeutics. Macromolecules, 35 (2). pp. 473-480. 10.1021/ma0108867.

Brocchini, S. (2001) Combinatorial chemistry and biomedical polymer development. Advanced Drug Delivery Reviews, 53 (1). pp. 123-130. 10.1016/S0169-409X(01)00224-1.

Zloh, M., Dinand, E. and Brocchini, S. (2001) Molecular modelling study of a degradable element for biomedical polymers. Internet Journal of Chemistry, 4 (9).

Searle, F., Gac-Breton, S., Keane, R., Dimitrijevic, S., Brocchini, S., Sausville, E.A. and Duncan, R. (2001) N-(2-Hydroxypropyl)methacrylamide Copolymer−6-(3-Aminopropyl)-ellipticine Conjugates. Synthesis, in Vitro, and Preliminary in Vivo Evaluation. Bioconjugate Chemistry, 12 (5). pp. 711-718. 10.1021/bc0001544.

Godwin, A., Hartenstein, M., Müller, A.H.E. and Brocchini, S. (2001) Narrow Molecular Weight Distribution Precursors for Polymer-Drug Conjugates. Angewandte Chemie (International ed. in English), 40 (3). pp. 594-597.

Godwin, A., Bolina, K., Clochard, M., Dinand, E., Rankin, S., Simic, S. and Brocchini, S. (2001) New strategies for polymer development in pharmaceutical science–a short review. Journal of Pharmacy and Pharmacology, 53 (9). pp. 1175-1184. 10.1211/0022357011776612.

Suárez, N., Brocchini, S. and Kohn, J.B. (2001) Relaxations and phase transitions phenomena in structurally related tyrosine-derived polyarylates. Radiation Effects and Defects in Solids, 155 (1-4). pp. 379-385. 10.1080/10420150108214141.

Suárez, N., Brocchini, S. and Kohn, J.B. (2001) Study of relaxation mechanisms in structurally related biomaterials by thermally stimulated depolarization currents. Polymer, 42 (21). pp. 8671-8680. 10.1016/S0032-3861(01)00437-2.

Belu, A.M., Brocchini, S., Kohn, J.B. and Ratner, B.D. (2000) Characterization of combinatorially designed polyarylates by time-of-flight secondary ion mass spectrometry. Rapid Communications in Mass Spectrometry, 14 (7). pp. 564-571.

Brocchini, S., James, K., Tangpasuthadol, V. and Kohn, J.B. (1998) Structure-property correlations in a combinatorial library of degradable biomaterials. Journal of Biomedical Materials Research, 42 (1). pp. 66-75.

Suarez, N., Brocchini, S. and Kohn, J.B. (1998) The study of water uptake in degradable polymers by thermally stimulated depolarization currents. Biomaterials, 19 (24). pp. 2347-2356. 10.1016/S0142-9612(98)00151-3.

Thomas, P.H., Sundaram, H., Krishek, B.J., Chazot, P.L., Xie, X., Bevan, P., Brocchini, S., Latham, C.J., Charlton, P., Moore, M., Lewis, S.J., Thornton, D.M., Stephenson, F.A. and Smart, T.G. (1997) Regulation of neuronal and recombinant GABA(A) receptor ion channels by xenovulene A, a natural product isolated from Acremonium strictum. Journal of Pharmacology and Experimental Therapeutics, 282 (2). pp. 513-520.

This list was generated on Fri Apr 18 09:41:08 2014 BST.