Browse by Person

Up a level
Export as [feed] RSS 2.0 [feed] RSS 1.0 [feed] Atom
Group by: Item Type | Date | No Grouping
Number of items: 24.

2012

Wangteeraprasert, R., Lipipun, V., Gunaratnam, M., Neidle, S., Gibbons, S. and Likhitwitayawuid, K. (2012) Bioactive Compounds from Carissa spinarum. Phytotherapy Research . 10.1002/ptr.4607.

Baud, M.G.J., Leiser, T., Haus, P., Samlal, S., Wong, A.C., Wood, R.J., Petrucci, V., Gunaratnam, M., Hughes, S.M., Buluwela, L., Turlais, F., Neidle, S., Meyer-Almes, F-J., White, A.J.P. and Fuchter, M.J. (2012) Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets. Journal of Medicinal Chemistry, 55 (4). pp. 1731-1750. 10.1021/jm2016182.

Campbell, N.H., Karim, N.H.A., Parkinson, G.N., Gunaratnam, M., Petrucci, V., Todd, A.K., Vilar, R. and Neidle, S. (2012) Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes. Journal of Medicinal Chemistry, 55 (1). pp. 209-222. 10.1021/jm201140v.

2011

Gunaratnam, M., Fuente, M.de la, Hampel, S.M., Todd, A.K., Reszka, A.P., Schatzlein, A.G. and Neidle, S. (2011) Targeting pancreatic cancer with a G-quadruplex ligand. Bioorganic & Medicinal Chemistry Letters, 19 (23). pp. 7151-7157. 1016/j.bmc.2011.09.055.

2010

Gunaratnam, M. and Neidle, S. (2010) An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells. In: Drug-DNA Interaction Protocols. Methods in molecular biology (613 ). Humana Press, NJ, USA, pp. 303-13. ISBN 978-1-60327-417-3. 10.1007/978-1-60327-418-0_19.

Sparapani, S., Bellini, S., Gunaratnam, M., Haider, S.M., Andreani, A., Rambaldi, M., Locatelli, A., Morigi, R., Granaiola, M., Varoli, L., Burnelli, S., Leoni, A. and Neidle, S. (2010) Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chemical Communications, 46 (31). pp. 5680-5682. 10.1039/c0cc00020e.

Bejugam, M., Gunaratnam, M., Müller, S., Sanders, D.A., Sewitz, S., Fletcher, J.A., Neidle, S. and Balasubramanian, S. (2010) Correction to Targeting thec-KitPromoter G-quadruplexes with 6-Substituted Indenoisoquinolines. ACS Medicinal Chemistry Letters, 1 (9). p. 546. 10.1021/ml100241w.

Sparapani, S., Haider, S.M., Doria, F., Gunaratnam, M. and Neidle, S. (2010) Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. Journal of the American Chemical Society, 132 (35). pp. 12263-12272. 10.1021/ja1003944.

Bejugam, M., Gunaratnam, M., Müller, S., Sanders, D.A., Sewitz, S., Fletcher, J.A., Neidle, S. and Balasubramanian, S. (2010) Targeting thec-KitPromoter G-quadruplexes with 6-Substituted Indenoisoquinolines. ACS Medicinal Chemistry Letters, 1 (7). pp. 306-310.

Hampel, Sonja M, Sidibe, Assitan, Gunaratnam, M., Riou, Jean-Francois and Neidle, S. (2010) Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorganic & Medicinal Chemistry Letters, 20 (22). pp. 6459-63. 10.1016/j.bmcl.2010.09.066 .

2009

Gunaratnam, M., Green, C., Moreira, J.B., Moorhouse, A.D., Kelland, L.R., Moses, J.E. and Neidle, S. (2009) G-quadruplex compounds and cisplatin act synergistically to inhibit cancer cell growth in vitro and in vivo. Biochemical Pharmacology, 78 (2). pp. 115-122. 10.1016/j.bcp.2009.03.018 .

Rahman, K.M., Reszka, A.P., Gunaratnam, M., Haider, S.M., Howard, P.W., Fox, K.R., Neidle, S. and Thurston, D.E. (2009) Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Chemical Communications, 27 . pp. 4097-4099. 10.1039/b902359c.

Gibbons, S., O'Donnell, G., Poeschl, R., Zimhony, O., Gunaratnam, M., Moreira, J.B., Neidle, S., Evangelopoulos, D., Bhakta, S., Malkinson, J.P., Boshoff, H. and Lenaerts, A. (2009) Bioactive pyridine-N-oxide disulphides from Allium stipitatum. Journal of Natural Products, 72 (3). pp. 360-365. 10.1021/np800572r.

Gunaratnam, M., Swank, S., Haider, S.M., Galesa, K., Reszka, A.P., Beltran, M., Cuenca, F., Fletcher, J.A. and Neidle, S. (2009) Targeting human gastrointestinal stromal tumour cells with a quadruplex-binding small molecule. Journal of Medicinal Chemistry, 52 (12). pp. 3774-3783. 10.1021/jm900424a.

2008

Drewe, W.C., Nanjunda, R., Gunaratnam, M., Beltran, M., Parkinson, G.N., Reszka, A.P., Wilson, W.D. and Neidle, S. (2008) Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. Journal of Medicinal Chemistry, 51 (24). pp. 7751-7767. 10.1021/jm801245v.

Cuenca, F., Greciano, O., Gunaratnam, M., Haider, S.M., Munnur, D., Nanjunda, R., Wilson, W.D. and Neidle, S. (2008) Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorganic and Medicinal Chemistry Letters, 18 (5). pp. 1668-1673. 10.1016/j.bmcl.2008.01.050.

Moorhouse, A.D., Gunaratnam, M., Haider, S.M., Munnur, D., Neidle, S. and Moses, J.E. (2008) Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Molecular Biosystems, 4 (6). pp. 629-642. 10.1039/b801822g.

Reed, J.E., Gunaratnam, M., Beltran, M., Reszka, A.P., Vilar, R. and Neidle, S. (2008) TRAP-LIG, a modified TRAP assay to quantitate telomerase inhibition by small molecules. Analytical Biochemistry, 380 . pp. 99-105. 10.1016/j.ab.2008.05.013.

2007

Martins, C., Gunaratnam, M., Stuart, J., Makwana, V., Greciano, O., Reszka, A.P., Kelland, L.R. and Neidle, S. (2007) Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorganic and Medicinal Chemistry Letters, 17 (8). pp. 2293-2298. 10.1016/j.bmcl.2007.01.056.

Milroy, L.G., Zinzalla, G., Prencipe, G., Michel, P., Ley, S.V., Gunaratnam, M., Beltran, M. and Neidle, S. (2007) Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. Angewandte Chemie, 46 (14). pp. 2493-2496. 10.1002/anie.200604688.

Gunaratnam, M., Greciano, O., Martins, C., Reszka, A.P., Schultes, C.M., Morjani, H., Riou, Jean-Francois and Neidle, S. (2007) Mechanism of acridine-based telomerase inhibition and telomere shortening. Biochemical Pharmacology, 74 (5). pp. 679-689. 10.1016/j.bcp.2007.06.011.

2006

Le Sann, C., Baron, A., Mann, J., van den Berg, H., Gunaratnam, M. and Neidle, S. (2006) New mustard-linked 2-aryl-bis-benzimadazoles with anti-proliferative activity. Organic and Biomolecular Chemistry, 4 . pp. 1305-1312. 10.1039/b600567e.

Moorhouse, A.D., Santos, A.M., Gunaratnam, M., Moore, M.J.B., Neidle, S. and Moses, J.E. (2006) Stabilisation of G-quadruplex DNA by highly specific ligands via click chemistry. Journal of the American Chemical Society, 128 (50). pp. 15972-15973. 10.1021/ja0661919.

Moore, M.J.B., Schultes, C.M., Cuesta, J., Cuenca, F., Gunaratnam, M., Tanious, F.A., Wilson, W.D. and Neidle, S. (2006) Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3, 6- and 9-side chains on quadruplex binding, telomerase activity and cell proliferation. Journal of Medicinal Chemistry, 49 . pp. 582-599. 10.1021/jm050555a.

This list was generated on Wed Aug 20 03:46:21 2014 BST.