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Number of items: 23.

2011

Haider, S.M., Autiero, I. and Neidle, S. (2011) Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes. Biochimie, 93 (8). pp. 1275-1279. 10.1016/j.biochi.2011.05.014.

Haider, S.M., Neidle, S. and Parkinson, G.N. (2011) A structural analysis of G-quadruplex/ligand interactions. Biochimie, 93 (8). pp. 1239-1251. 10.1016/j.biochi.2011.05.012.

Haider, S.M., Joseph, C.G., Neidle, S., Fierke, C.A. and Fuchter, M.J. (2011) On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorganic & Medicinal Chemistry Letters, 21 (7). pp. 2129-2132. 10.1016/j.bmcl.2011.01.128.

Petraccone, L., Fotticchia, I., Cummaro, A., Pagano, B., Ginnari-Satriani, L., Haider, S.M., Randazzo, A., Novellino, E., Neidle, S. and Giancola, C. (2011) The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies. Biochimie, 93 (8). pp. 1318-1327. 10.1016/j.biochi.2011.05.017.

2010

Haider, S.M., Patel, J., Poojari, C. and Neidle, S. (2010) Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. Journal of Molecular Biology, 400 (5). pp. 1078-1098. 10.1016/j.jmb.2010.05.069 .

Moses, J., Ritson, D., Zhang, F., Lombardo, C.M., Haider, S.M., Oldham, N. and Neidle, S. (2010) A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Organic and Biomolecular Chemistry, 8 (13). pp. 2926-2930. 10.1039/c005055e.

Collie, G.W., Haider, S.M., Neidle, S. and Parkinson, G.N. (2010) A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Research . 10.1093/nar/gkq259 .

Zinzalla, G., Haque, M.R., Basu, B Piku, Anderson, J., Kaye, S.L., Haider, S.M., Hasan, F., Antonow, D., Essex, S., Rahman, K.M., Palmer, J., Morgenstern, D., Wilderspin, A.F., Neidle, S. and Thurston, D.E. (2010) A novel small-molecule inhibitor of IL-6 signalling. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7029-32. 10.1016/j.bmcl.2010.09.117.

Sparapani, S., Bellini, S., Gunaratnam, M., Haider, S.M., Andreani, A., Rambaldi, M., Locatelli, A., Morigi, R., Granaiola, M., Varoli, L., Burnelli, S., Leoni, A. and Neidle, S. (2010) Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chemical Communications, 46 (31). pp. 5680-5682. 10.1039/c0cc00020e.

Haider, S.M. and Neidle, S. (2010) Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. In: G-Quadruplex DNA: Methods and Protocols. Methods in molecular biology (608). Humana Press, NJ, USA, pp. 17-37. ISBN 978-1588299505 . 10.1007/978-1-59745-363-9_2.

Sparapani, S., Haider, S.M., Doria, F., Gunaratnam, M. and Neidle, S. (2010) Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. Journal of the American Chemical Society, 132 (35). pp. 12263-12272. 10.1021/ja1003944.

Lombardo, C.M., Martínez, I.S., Haider, S.M., Gabelica, V., De Pauw, E., Moses, J.E. and Neidle, S. (2010) Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chemical Communications, 46 (48). pp. 9116-9118. 10.1039/C0CC02917C.

2009

Haider, S.M. and Neidle, S. (2009) A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. Biochemical Society Transactions, 37 (3). pp. 583-588. 10.1042/BST0370583.

Rahman, K.M., Reszka, A.P., Gunaratnam, M., Haider, S.M., Howard, P.W., Fox, K.R., Neidle, S. and Thurston, D.E. (2009) Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Chemical Communications, 27 . pp. 4097-4099. 10.1039/b902359c.

Tai, K., Haider, S.M., Grottesi, A. and Sansom, M.S.P. (2009) Ion channel gates: comparative analysis of energy barriers. European Biophysics Journal, 38 (4). pp. 347-354. doi:10.1007/s00249-008-0377-x.

Collie, G.W., Reszka, A.P., Haider, S.M., Gabelica, V., Parkinson, G.N. and Neidle, S. (2009) Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chemical Communications, 48 . pp. 7482-7484. 10.1039/b901889a.

Gunaratnam, M., Swank, S., Haider, S.M., Galesa, K., Reszka, A.P., Beltran, M., Cuenca, F., Fletcher, J.A. and Neidle, S. (2009) Targeting human gastrointestinal stromal tumour cells with a quadruplex-binding small molecule. Journal of Medicinal Chemistry, 52 (12). pp. 3774-3783. 10.1021/jm900424a.

2008

Haider, S.M., Parkinson, G.N. and Neidle, S. (2008) Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophysical Journal, 95 (1). pp. 296-311. 10.1529/biophysj.107.120501.

Cuenca, F., Greciano, O., Gunaratnam, M., Haider, S.M., Munnur, D., Nanjunda, R., Wilson, W.D. and Neidle, S. (2008) Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorganic and Medicinal Chemistry Letters, 18 (5). pp. 1668-1673. 10.1016/j.bmcl.2008.01.050.

Moorhouse, A.D., Gunaratnam, M., Haider, S.M., Munnur, D., Neidle, S. and Moses, J.E. (2008) Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Molecular Biosystems, 4 (6). pp. 629-642. 10.1039/b801822g.

2007

Todd, A.K., Haider, S.M., Parkinson, G.N. and Neidle, S. (2007) Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Research, 35 (17). pp. 5799-5808. 10.1093/nar/gkm609.

2004

Harrison, R.J., Reszka, A.P., Haider, S.M., Romagnoli, B., Morrell, J., Read, M.A., Gowan, S.M., Incles, C.M., Kelland, L.R. and Neidle, S. (2004) Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorganic and Medicinal Chemistry Letters, 14 (23). pp. 5845-5849. 10.1016/j.bmcl.2004.09.037.

2003

Haider, S.M., Parkinson, G.N. and Neidle, S. (2003) Structure of a G-quadruplex–Ligand Complex. Journal of Molecular Biology, 326 (1). pp. 117-125. 10.1016/S0022-2836(02)01354-2.

This list was generated on Sat Dec 20 19:27:12 2014 GMT.