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Number of items: 130.

2012

Wangteeraprasert, R., Lipipun, V., Gunaratnam, M., Neidle, S., Gibbons, S. and Likhitwitayawuid, K. (2012) Bioactive Compounds from Carissa spinarum. Phytotherapy Research . 10.1002/ptr.4607.

Baud, M.G.J., Leiser, T., Haus, P., Samlal, S., Wong, A.C., Wood, R.J., Petrucci, V., Gunaratnam, M., Hughes, S.M., Buluwela, L., Turlais, F., Neidle, S., Meyer-Almes, F-J., White, A.J.P. and Fuchter, M.J. (2012) Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets. Journal of Medicinal Chemistry, 55 (4). pp. 1731-1750. 10.1021/jm2016182.

Davies, J.E., Neidle, S. and Taylor, D.G. (2012) Developing and paying for medicines for orphan indications in oncology: utilitarian regulation vs equitable care? British Journal of Cancer, 106 (1). pp. 14-17. 10.1038/bjc.2011.544.

Rahman, K.M., Tizkova, K., Reszka, A.P., Neidle, S. and Thurston, D.E. (2012) Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. Bioorganic and Medicinal Chemistry Letters, 22 (8). pp. 3006-3010. 10.1016/j.bmcl.2012.02.020.

Campbell, N.H., Karim, N.H.A., Parkinson, G.N., Gunaratnam, M., Petrucci, V., Todd, A.K., Vilar, R. and Neidle, S. (2012) Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes. Journal of Medicinal Chemistry, 55 (1). pp. 209-222. 10.1021/jm201140v.

Collie, G.W., Promontorio, R., Hampel, S.M., Micco, M., Neidle, S. and Parkinson, G.N. (2012) Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands. Journal of the American Chemical Society, 134 (5). pp. 2723-2731. 10.1021/ja2102423.

2011

Gunaratnam, M., Fuente, M.de la, Hampel, S.M., Todd, A.K., Reszka, A.P., Schatzlein, A.G. and Neidle, S. (2011) Targeting pancreatic cancer with a G-quadruplex ligand. Bioorganic & Medicinal Chemistry Letters, 19 (23). pp. 7151-7157. 1016/j.bmc.2011.09.055.

Neidle, S. (2011) Therapeutic Applications of Quadruplex Nucleic Acids. Academic Press. ISBN 978-0123751386 .

Haider, S.M., Autiero, I. and Neidle, S. (2011) Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes. Biochimie, 93 (8). pp. 1275-1279. 10.1016/j.biochi.2011.05.014.

Todd, A.K. and Neidle, S. (2011) Mapping the sequences of potential guanine quadruplex motifs. Nucleic Acids Research . 10.1093/nar/gkr104 .

Haider, S.M., Neidle, S. and Parkinson, G.N. (2011) A structural analysis of G-quadruplex/ligand interactions. Biochimie, 93 (8). pp. 1239-1251. 10.1016/j.biochi.2011.05.012.

Campbell, N.H., Smith, D.L., Reszka, A.P., Neidle, S. and O'Hagan, D. (2011) Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Organic & biomolecular chemistry, 9 (5). pp. 1328-1331. doi:10.1039/c0ob00886a.

Campbell, N.H. and Neidle, S. (2011) G-Quadruplexes and Metal Ions. Metal Ions in Life Sciences, 10 . pp. 119-134. 10.1007/978-94-007-2172-2_4.

Casagrande, V., Salvati, E., Alvino, A., Bianco, A., Ciammaichella, A., D'Angelo, C., Ginnari-Satriani, L., Serrilli, A.M., Iachettini, S., Leonetti, C., Neidle, S., Ortaggi, G., Porru, M., Rizzo, A., Franceschin, M. and Biroccio, A. (2011) N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage. Journal of Medicinal Chemistry . 10.1021/jm1013665 .

Haider, S.M., Joseph, C.G., Neidle, S., Fierke, C.A. and Fuchter, M.J. (2011) On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorganic & Medicinal Chemistry Letters, 21 (7). pp. 2129-2132. 10.1016/j.bmcl.2011.01.128.

Collie, G.W., Sparapani, S., Parkinson, G.N. and Neidle, S. (2011) Structural basis of telomeric RNA quadruplex-acridine ligand recognition. Journal of the American Chemical Society, 133 (8). pp. 2721-2728. 10.1021/ja109767y.

Balasubramanian, S., Hurley, L.H. and Neidle, S. (2011) Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nature Reviews. Drug discovery, 10 (4). pp. 261-275. 10.1038/nrd3428.

Petraccone, L., Fotticchia, I., Cummaro, A., Pagano, B., Ginnari-Satriani, L., Haider, S.M., Randazzo, A., Novellino, E., Neidle, S. and Giancola, C. (2011) The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies. Biochimie, 93 (8). pp. 1318-1327. 10.1016/j.biochi.2011.05.017.

Liu, Y., Kumar, A., Depauw, S., Nhili, R., David-Cordonnier, M-H., Lee, M.P., Ismail, M.A., Farahat, A.A., Say, M., Chackal-Catoen, S., Batista-Parra, A., Neidle, S., Boykin, D.W. and Wilson, W.D. (2011) Water-Mediated Binding of Agents that Target the DNA Minor Groove. Journal of the American Chemical Society, 133 (26). pp. 10171-10183. 10.1021/ja202006u.

2010

Neidle, S. (2010) Methods for studying quadruplex nucleic acids. Current Opinion in Structural Biology, 43 (4). p. 245. 10.1016/j.ymeth.2007.10.001.

Haider, S.M., Patel, J., Poojari, C. and Neidle, S. (2010) Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. Journal of Molecular Biology, 400 (5). pp. 1078-1098. 10.1016/j.jmb.2010.05.069 .

Moses, J., Ritson, D., Zhang, F., Lombardo, C.M., Haider, S.M., Oldham, N. and Neidle, S. (2010) A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Organic and Biomolecular Chemistry, 8 (13). pp. 2926-2930. 10.1039/c005055e.

Collie, G.W., Parkinson, G.N., Neidle, S., Rosu, F., De Pauw, E. and Gabelica, V. (2010) Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. Journal of the American Chemical Society . 10.1021/ja100345z.

Collie, G.W., Haider, S.M., Neidle, S. and Parkinson, G.N. (2010) A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Research . 10.1093/nar/gkq259 .

Gunaratnam, M. and Neidle, S. (2010) An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells. In: Drug-DNA Interaction Protocols. Methods in molecular biology (613 ). Humana Press, NJ, USA, pp. 303-13. ISBN 978-1-60327-417-3. 10.1007/978-1-60327-418-0_19.

Zinzalla, G., Haque, M.R., Basu, B Piku, Anderson, J., Kaye, S.L., Haider, S.M., Hasan, F., Antonow, D., Essex, S., Rahman, K.M., Palmer, J., Morgenstern, D., Wilderspin, A.F., Neidle, S. and Thurston, D.E. (2010) A novel small-molecule inhibitor of IL-6 signalling. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7029-32. 10.1016/j.bmcl.2010.09.117.

Sparapani, S., Bellini, S., Gunaratnam, M., Haider, S.M., Andreani, A., Rambaldi, M., Locatelli, A., Morigi, R., Granaiola, M., Varoli, L., Burnelli, S., Leoni, A. and Neidle, S. (2010) Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chemical Communications, 46 (31). pp. 5680-5682. 10.1039/c0cc00020e.

Lavrado, J., Reszka, A.P., Moreira, R., Neidle, S. and Paulo, A. (2010) C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7042-5. 10.1016/j.bmcl.2010.09.110.

Bejugam, M., Gunaratnam, M., Müller, S., Sanders, D.A., Sewitz, S., Fletcher, J.A., Neidle, S. and Balasubramanian, S. (2010) Correction to Targeting thec-KitPromoter G-quadruplexes with 6-Substituted Indenoisoquinolines. ACS Medicinal Chemistry Letters, 1 (9). p. 546. 10.1021/ml100241w.

Neidle, S. (2010) Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS Journal, 277 (5). pp. 1118-1125. 10.1111/j.1742-4658.2009.07463.x.

Haider, S.M. and Neidle, S. (2010) Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. In: G-Quadruplex DNA: Methods and Protocols. Methods in molecular biology (608). Humana Press, NJ, USA, pp. 17-37. ISBN 978-1588299505 . 10.1007/978-1-59745-363-9_2.

Sparapani, S., Haider, S.M., Doria, F., Gunaratnam, M. and Neidle, S. (2010) Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. Journal of the American Chemical Society, 132 (35). pp. 12263-12272. 10.1021/ja1003944.

Lombardo, C.M., Martínez, I.S., Haider, S.M., Gabelica, V., De Pauw, E., Moses, J.E. and Neidle, S. (2010) Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chemical Communications, 46 (48). pp. 9116-9118. 10.1039/C0CC02917C.

Antonow, D., Kaliszczak, M., Kang, G.D., Coffils, M.J., Tiberghien, A.C., Cooper, N., Barata, T.S., Heidelberger, S., James, C.H., Zloh, M., Jenkins, T.C., Reszka, A.P., Neidle, S., Guichard, S.M., Jodrell, D.I., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2010) Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents. Journal of Medicinal Chemistry, 53 (7). pp. 2927-2941. 10.1021/jm901722v.

Bejugam, M., Gunaratnam, M., Müller, S., Sanders, D.A., Sewitz, S., Fletcher, J.A., Neidle, S. and Balasubramanian, S. (2010) Targeting thec-KitPromoter G-quadruplexes with 6-Substituted Indenoisoquinolines. ACS Medicinal Chemistry Letters, 1 (7). pp. 306-310.

Hampel, Sonja M, Sidibe, Assitan, Gunaratnam, M., Riou, Jean-Francois and Neidle, S. (2010) Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorganic & Medicinal Chemistry Letters, 20 (22). pp. 6459-63. 10.1016/j.bmcl.2010.09.066 .

2009

Gunaratnam, M., Green, C., Moreira, J.B., Moorhouse, A.D., Kelland, L.R., Moses, J.E. and Neidle, S. (2009) G-quadruplex compounds and cisplatin act synergistically to inhibit cancer cell growth in vitro and in vivo. Biochemical Pharmacology, 78 (2). pp. 115-122. 10.1016/j.bcp.2009.03.018 .

Micheli, E., Lombardo, C.M., D'Ambrosio, D., Franceschin, M., Neidle, S. and Savino, M. (2009) Selective G-quadruplex ligands: the significant role of side chain charge density in a series of perylene derivatives. Bioorganic and Medicinal Chemistry Letters, 19 (14). pp. 3903-3908. 10.1016/j.bmcl.2009.03.106.

Haider, S.M. and Neidle, S. (2009) A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. Biochemical Society Transactions, 37 (3). pp. 583-588. 10.1042/BST0370583.

Balasubramanian, S. and Neidle, S. (2009) G-quadruplex nucleic acids as therapeutic targets. Current Opinion in Chemical Biology, 13 (3). pp. 345-353. 10.1016/j.cbpa.2009.04.637 .

Neidle, S. (2009) The structures of quadruplex nucleic acids and their drug complexes. Current Opinion in Structural Biology, 19 (3). pp. 239-250. 10.1016/j.sbi.2009.04.001 .

Nguyen, B., Neidle, S. and Wilson, W.D. (2009) A role for water molecules in DNA−ligand minor groove recognition. Accounts of Chemical Research, 42 (1). pp. 11-21. 10.1021/ar800016q.

Hsu, S.T.D., Varnai, P., Reszka, A.P., Neidle, S. and Balasubramanian, S. (2009) A G-rich sequence with the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. Journal of the American Chemical Society, 131 (37). pp. 13399-13409. 10.1021/ja904007p.

Rahman, K.M., Reszka, A.P., Gunaratnam, M., Haider, S.M., Howard, P.W., Fox, K.R., Neidle, S. and Thurston, D.E. (2009) Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Chemical Communications, 27 . pp. 4097-4099. 10.1039/b902359c.

Gibbons, S., O'Donnell, G., Poeschl, R., Zimhony, O., Gunaratnam, M., Moreira, J.B., Neidle, S., Evangelopoulos, D., Bhakta, S., Malkinson, J.P., Boshoff, H. and Lenaerts, A. (2009) Bioactive pyridine-N-oxide disulphides from Allium stipitatum. Journal of Natural Products, 72 (3). pp. 360-365. 10.1021/np800572r.

Cuenca, F., Moore, M.J.B., Johnson, K., Guyen, B., De Cian, A. and Neidle, S. (2009) Design, synthesis and evaluation of 4,5-disubstituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells. Bioorganic and Medicinal Chemistry Letters, 19 (17). pp. 5109-5113. 10.1016/j.bmcl.2009.07.033 .

Reed, J.E., White, A.J.P., Neidle, S. and Vilar, R. (2009) Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA. Journal of the Chemical Society, Dalton Transactions (14). pp. 2558-2568. 10.1039/b820086f.

Neidle, S., Schneider, B. and Berman, H.M. (2009) Fundamentals of DNA and RNA structure. In: Structural Bioinformatics. John Wiley & Sons Inc., pp. 41-77. ISBN 0470181052 .

Redman, J.E., Granadino-Roldan, J.M., Schouten, J.A., Ladame, S., Reszka, A.P., Neidle, S. and Balasubramanian, S. (2009) Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Organic and Biomolecular Chemistry, 7 . pp. 76-84. 10.1039/b814682a.

Campbell, N.H., Patel, M., Tofa, A., Ghosh, R., Parkinson, G.N. and Neidle, S. (2009) Selectivity in ligand recognition of G-quadruplex loops. Biochemistry, 48 (1). pp. 1675-1680. 10.1021/bi802233v.

Collie, G.W., Reszka, A.P., Haider, S.M., Gabelica, V., Parkinson, G.N. and Neidle, S. (2009) Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chemical Communications, 48 . pp. 7482-7484. 10.1039/b901889a.

Martino, L., Pagano, B., Fotticchia, I., Neidle, S. and Giancola, C. (2009) Shedding light on the interaction of TMPyP4 with human telomeric quadruplexes. Journal of Physical Chemistry B, 113 (44). pp. 14779-14786. 10.1021/jp9066394.

Gunaratnam, M., Swank, S., Haider, S.M., Galesa, K., Reszka, A.P., Beltran, M., Cuenca, F., Fletcher, J.A. and Neidle, S. (2009) Targeting human gastrointestinal stromal tumour cells with a quadruplex-binding small molecule. Journal of Medicinal Chemistry, 52 (12). pp. 3774-3783. 10.1021/jm900424a.

2008

Drewe, W.C., Nanjunda, R., Gunaratnam, M., Beltran, M., Parkinson, G.N., Reszka, A.P., Wilson, W.D. and Neidle, S. (2008) Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. Journal of Medicinal Chemistry, 51 (24). pp. 7751-7767. 10.1021/jm801245v.

Zagotto, G., Sissi, C., Lucatello, L., Pivetta, C., Cadamuro, S.A., Fox, K.R., Neidle, S. and Palumbo, M. (2008) Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. Journal of Medicinal Chemistry, 51 (18). pp. 5566-5574. 10.1021/jm800160v.

Neidle, S. and Parkinson, G.N. (2008) Quadruplex DNA crystal structures and drug design. Biochimie, 90 (8). pp. 1184-1190. 10.1016/j.biochi.2008.03.003.

Haider, S.M., Parkinson, G.N. and Neidle, S. (2008) Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophysical Journal, 95 (1). pp. 296-311. 10.1529/biophysj.107.120501.

Todd, A.K. and Neidle, S. (2008) The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Research, 36 (8). pp. 2700-2704. 10.1093/nar/gkn078.

Cuenca, F., Greciano, O., Gunaratnam, M., Haider, S.M., Munnur, D., Nanjunda, R., Wilson, W.D. and Neidle, S. (2008) Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorganic and Medicinal Chemistry Letters, 18 (5). pp. 1668-1673. 10.1016/j.bmcl.2008.01.050.

Zagotto, G., Sissi, C., Moro, S., Del Ben, D., Parkinson, G.N., Fox, S., Neidle, S. and Palumbo, M. (2008) Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorganic & Medicinal Chemistry, 16 (1). pp. 354-361. 10.1016/j.bmc.2007.09.040.

Drewe, W.C. and Neidle, S. (2008) Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers. Chemical Communications (42). pp. 5295-5297. 10.1039/b817545b.

Arola-Arnal, A., Benet, J., Neidle, S. and Vilar, R. (2008) Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorganic Chemistry, 47 . pp. 11910-11919. 10.1021/ic8016547.

Campbell, N.H., Parkinson, G.N., Reszka, A.P. and Neidle, S. (2008) Structural basis of DNA quadruplex recognition by an acridine drug. Journal of the American Chemical Society, 130 (21). pp. 6722-6724. 10.1021/ja8016973.

Moorhouse, A.D., Gunaratnam, M., Haider, S.M., Munnur, D., Neidle, S. and Moses, J.E. (2008) Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Molecular Biosystems, 4 (6). pp. 629-642. 10.1039/b801822g.

Parkinson, G.N., Cuenca, F. and Neidle, S. (2008) Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. Journal of Molecular Biology, 381 (5). pp. 1145-1156. 10.1016/j.jmb.2008.06.022.

Reed, J.E., Gunaratnam, M., Beltran, M., Reszka, A.P., Vilar, R. and Neidle, S. (2008) TRAP-LIG, a modified TRAP assay to quantitate telomerase inhibition by small molecules. Analytical Biochemistry, 380 . pp. 99-105. 10.1016/j.ab.2008.05.013.

2007

Neidle, S. (2007) Principles of Nucleic Acid Structure. Academic Press. ISBN 0123695074.

Neidle, S. (2007) Cancer Drug Design and Discovery. Academic Press. ISBN 0123694485.

Lee, M.P., Parkinson, G.N., Hazel, P. and Neidle, S. (2007) Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. Journal of the American Chemical Society, 129 (33). pp. 10106-10107. 10.1021/ja0740869.

Martins, C., Gunaratnam, M., Stuart, J., Makwana, V., Greciano, O., Reszka, A.P., Kelland, L.R. and Neidle, S. (2007) Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorganic and Medicinal Chemistry Letters, 17 (8). pp. 2293-2298. 10.1016/j.bmcl.2007.01.056.

Phan, A.T., Kuryavyi, V., Burge, S., Neidle, S. and Patel, D.J. (2007) Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. Journal of the American Chemical Society, 129 (14). pp. 4386-4392. 10.1021/ja068739h.

Davies, R.J., Malone, J.F., Gan, Y., Cardin, C.J., Lee, M.P. and Neidle, S. (2007) High-resolution crystal structure of the intramolecular d(TpA) thymine-adenine photoadduct and its mechanistic implications. Nucleic Acids Research, 35 (4). pp. 1048-1053. 10.1093/nar/gkl1101..

Parkinson, G.N., Ghosh, R. and Neidle, S. (2007) Structural basis for binding of porphyrin to human telomeres. Biochemistry, 46 (9). pp. 2390-2397. 10.1021/bi062244n.

White, E.W., Tanious, F.A., Ismail, M.A., Reszka, A.P., Neidle, S., Boykin, D.W. and Wilson, W.D. (2007) Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophysical Chemistry, 126 (1-3). pp. 140-153. 10.1016/j.bpc.2006.06.006.

Milroy, L.G., Zinzalla, G., Prencipe, G., Michel, P., Ley, S.V., Gunaratnam, M., Beltran, M. and Neidle, S. (2007) Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. Angewandte Chemie, 46 (14). pp. 2493-2496. 10.1002/anie.200604688.

Munde, M., Lee, M.P., Neidle, S., Arafa, R., Boykin, D.W., Liu, Y., Bailly, C. and Wilson, W.D. (2007) Induced Fit Conformational Changes of a “Reversed Amidine” Heterocycle:  Optimized Interactions in a DNA Minor Groove Complex. Journal of the American Chemical Society, 129 (17). p. 5688. 10.1021/ja069003n.

Gunaratnam, M., Greciano, O., Martins, C., Reszka, A.P., Schultes, C.M., Morjani, H., Riou, Jean-Francois and Neidle, S. (2007) Mechanism of acridine-based telomerase inhibition and telomere shortening. Biochemical Pharmacology, 74 (5). pp. 679-689. 10.1016/j.bcp.2007.06.011.

Neidle, S. (2007) Methods for studying quadruplex nucleic acids. Methods, 43 (4). p. 245. 10.1016/j.ymeth.2007.10.001.

Todd, A.K., Haider, S.M., Parkinson, G.N. and Neidle, S. (2007) Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Research, 35 (17). pp. 5799-5808. 10.1093/nar/gkm609.

Reed, J.E., Neidle, S. and Vilar, R. (2007) Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. Chemical Communications (42). pp. 4366-4368. 10.1039/B709898G .

Reed, J.E., Neidle, S. and Vilar, R. (2007) Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex. Chemical Communications (42). pp. 4366-4368. 10.1039/b709898g.

2006

Neidle, S., Balasubramanian, S., Campbell, S.F., Clore, M. and Lilley, David M.J., eds. (2006) Quadruplex nucleic acids. Royal Society of Chemistry. ISBN 0854043748.

Burge, Sarah, Parkinson, G.N., Hazel, P., Todd, A.K. and Neidle, S. (2006) Quadruplex DNA: sequence, topology and structure. Nucleic Acids Research, 34 (19). pp. 5402-5415. 10.1093/nar/gkl655.

Evans, David A. and Neidle, S. (2006) Virtual screening of DNA minor groove binders. Journal of Medicinal Chemistry, 49 . pp. 4232-4238. 10.1021/jm0601957.

Moore, M.J.B., Cuenca, F., Searcey, M. and Neidle, S. (2006) Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Organic and Biomolecular Chemistry, 4 . pp. 3479-3488. 10.1039/b607707b.

Fernando, Himesh, Reszka, A.P., Huppert, J., Ladame, S., Rankin, S., Venkitaraman, Ashok R., Neidle, S. and Balasubramanian, S. (2006) A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry, 45 . pp. 7854-7860. 10.1021/bi0601510.

Hazel, P., Parkinson, G.N. and Neidle, S. (2006) Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Research, 34 (7). pp. 2117-2127. 10.1093/nar/gkl182 .

Neidle, S. (2006) Structural bioinformatics in cancer. In: Cancer Bioinformatics. John Wiley and Sons Ltd.. ISBN 0470863048.

Ladame, S., Schouten, J.A., Roldan, J., Redman, J.E., Neidle, S. and Balasubramanian, S. (2006) Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry, 45 (5). pp. 1393-1399. 10.1021/bi050229x.

Redman, J.E., Ladame, S., Reszka, A.P., Neidle, S. and Balasubramanian, S. (2006) Discovery of G-quadruplex stabilising ligands through direct ELISA of a one-bead-compound library. Organic and Biomolecular Chemistry, 4 . pp. 4364-4369. 10.1039/b611716c.

Franceschin, M., Rossetti, L., D'Ambrosio, A., Schirripa, S., Bianco, A., Ortaggi, G., Savino, M., Schultes, C.M. and Neidle, S. (2006) Natural and synthetic G-quadruplex interactive berberine derivatives. Bioorganic and Medicinal Chemistry Letters, 16 (6). pp. 1707-1711. 10.1016/j.bmcl.2005.12.001.

Le Sann, C., Baron, A., Mann, J., van den Berg, H., Gunaratnam, M. and Neidle, S. (2006) New mustard-linked 2-aryl-bis-benzimadazoles with anti-proliferative activity. Organic and Biomolecular Chemistry, 4 . pp. 1305-1312. 10.1039/b600567e.

Moorhouse, A.D., Santos, A.M., Gunaratnam, M., Moore, M.J.B., Neidle, S. and Moses, J.E. (2006) Stabilisation of G-quadruplex DNA by highly specific ligands via click chemistry. Journal of the American Chemical Society, 128 (50). pp. 15972-15973. 10.1021/ja0661919.

Reed, J.E., Arnal, Anna Arola, Neidle, S. and Vilar, R. (2006) Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. Journal of the American Chemical Society, 128 . pp. 5992-5993. 10.1021/ja058509n.

Campbell, N.H., Evans, D.H., Lee, M.P.H., Parkinson, G.N. and Neidle, S. (2006) Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure. Bioorganic and Medicinal Chemistry Letters, 16 (1). pp. 15-19. 10.1016/j.bmcl.2005.10.036.

Neidle, S. (2006) The discovery of G-quadruplex telomere targeting drugs. In: Sequence-Specific DNA binding agents. Royal Society of Chemistry, pp. 190-206.

Hazel, P., Parkinson, G.N. and Neidle, S. (2006) Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. Journal of the American Chemical Society, 128 . pp. 5480-5487. 10.1021/ja058577+.

Moore, M.J.B., Schultes, C.M., Cuesta, J., Cuenca, F., Gunaratnam, M., Tanious, F.A., Wilson, W.D. and Neidle, S. (2006) Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3, 6- and 9-side chains on quadruplex binding, telomerase activity and cell proliferation. Journal of Medicinal Chemistry, 49 . pp. 582-599. 10.1021/jm050555a.

2005

Miao, Y., Lee, M.P., Parkinson, G.N., Batista-Parra, A., Ismail, M.A., Neidle, S., Boykin, D.W. and Wilson, W.D. (2005) Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry, 44 (45). pp. 14701-14708. 10.1016/j.bpc.2006.06.006.

Neidle, S. and Thurston, D.E. (2005) The role of chemical sciences in 21st century cancer drug discovery. Discovery Medicine, 5 (29). pp. 450-454.

Neidle, S. and Thurston, D.E. (2005) Chemical approaches to the discovery and development of cancer therapies. Nature Reviews Cancer, 5 (4). pp. 285-296. 10.1038/nrc1587.

Burger, A.M., Dai, F., Schultes, C.M., Reszka, A.P., Moore, M.J.B., Double, J.A. and Neidle, S. (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Research, 65 (4). pp. 1489-1496. 10.1158/0008-5472.CAN-04-2910 .

Casely-Heyford, M.A., Pors, K., Patterson, L.H., Gemer, C., Neidle, S. and Searcey, M. (2005) Truncated azinomycin analogues intercalate into DNA. Bioorganic and Medicinal Chemistry Letters, 15 (3). pp. 653-656. 10.1016/j.bmcl.2004.11.037.

Burger, A.M., Dai, F., Schultes, C.M., Reszka, A.P., Moore, M.J.B. and Neidle, S. (2005) A G-quadruplex binding telomerase inhibitor with invivo anticancer activity. Cancer Research, 65 (4). pp. 1489-1496.

Todd, A. K., Johnston, M. and Neidle, S. (2005) Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Research, 33 (9). pp. 2901-2907. 10.1093/nar/gki553.

Rankin, S., Reszka, A.P., Huppert, J., Zloh, M., Parkinson, G.N., Todd, A.K., Ladame, S., Balasubramanian, S. and Neidle, S. (2005) Putative DNA quadruplex formation within the human c-kit oncogene. Journal of the American Chemical Society, 127 . pp. 10584-10589. 10.1021/ja050823u.

Burger, A.M., Dai, F., Schultes, C.M., Reszka, A.P., Moore, M.J.B., Double, J.A. and Neidle, S. (2005) The G-Quadruplex-Interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent with Telomere Targeting and Interference with Telomerase Function. Cancer Research, 65 (4). pp. 1489-1496. 10.1158/0008-5472.CAN-04-2910.

2004

Hazel, P., Huppert, J., Balasubramanian, S. and Neidle, S. (2004) Loop-length-dependent folding of G-quadruplexes. Journal of the American Chemical Society, 126 (50). pp. 16405-16415. 10.1021/ja045154j.

Harrison, R.J., Reszka, A.P., Haider, S.M., Romagnoli, B., Morrell, J., Read, M.A., Gowan, S.M., Incles, C.M., Kelland, L.R. and Neidle, S. (2004) Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorganic and Medicinal Chemistry Letters, 14 (23). pp. 5845-5849. 10.1016/j.bmcl.2004.09.037.

Mallena, S., Lee, M.P., Bailly, C., Neidle, S., Kumar, A., Boykin, D.W. and Wilson, W.D. (2004) Thiophene-based diamidine forms a "super" at binding minor groove agent. Journal of the American Chemical Society, 126 (42). pp. 13659-136569. 10.1021/ja048175m.

Ladame, S., Schouten, J.A., Stuart, J., Roldan, J., Neidle, S. and Balasubramanian, S. (2004) Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. Organic and Biomolecular Chemistry, 2 (20). pp. 2925-2931. 10.1039/B409698C .

Schultes, C.M., Guyen, B., Cuesta, J. and Neidle, S. (2004) Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors. Bioorganic and Medicinal Chemistry Letters, 14 (16). pp. 4347-4351. 10.1016/j.bmcl.2004.05.090 .

Guyen, B., Schultes, C.M., Hazel, P., Mann, J. and Neidle, S. (2004) Synthesis and evaluation of analogues of 10H-indolo[3,2-b] quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Organic and Biomolecular Chemistry, 2 (7). pp. 981-989. 10.1039/B316055F .

Nguyen, B., Hamelberg, D., Bailly, C., Colson, P., Stanek, J., Brun, R., Neidle, S. and Wilson, W.D. (2004) Characterization of a novel DNA minor-groove complex. Biophysical Journal, 86 (2). pp. 1028-1041. PMC1303896.

Incles, C.M., Schultes, C.M, Kempski, H., Koehler, H., Kelland, L.R. and Neidle, S. (2004) A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Molecular Cancer Therapeutics, 3 (10). pp. 1201-1206.

De Souza, J. and Neidle, S. (2004) Stephen Neidle on cancer therapy and G-quadruplex inhibitors. Drug Discovery Today, 9 (18). pp. 778-781. 10.1016/S1359-6446(04)03214-3.

2003

Incles, C.M., Schultes, C.M., Kelland, L.R. and Neidle, S. (2003) Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor. Molecular Pharmacology, 64 (5). pp. 1101-1108. 10.1124/mol.64.5.1101.

Seaton, A., Higgins, C., Mann, J., Bailly, C., Neidle, S. and van den Berg, H. (2003) Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles. European Journal of Cancer, 39 (17). pp. 2548-2555. 10.1016/S0959-8049(03)00621-X .

Harrison, R.J., Cuesta, J., Chessari, G., Read, M.A., Basra, S.K., Reszka, A.P., Morrell, J., Gowan, S.M., Incles, C.M., Tanious, F.A., Wilson, W.D., Kelland, L.R. and Neidle, S. (2003) Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. Journal of Medicinal Chemistry, 46 (21). pp. 4463-4476. 10.1021/jm0308693.

Johansson, E., Parkinson, G.N., Denny, W.A. and Neidle, S. (2003) Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the nhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. Journal of Medicinal Chemistry, 46 (19). pp. 4009-4020. 10.1021/jm030843b.

Parkinson, G.N. and Neidle, S. (2003) The structure of telomeric DNA. Current Opinion in Structural Biology, 13 (3). pp. 275-283. 10.1016/S0959-440X(03)00072-1.

Joubert, A., Sun, X.W., Johansson, E., Bailly, C., Mann, J. and Neidle, S. (2003) Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole. Biochemistry, 42 (20). pp. 5984-5992. 10.1021/bi026926w.

Clark, G.R., Pytel, P.D., Squire, C.J. and Neidle, S. (2003) Structure of the first parallel DNA quadruplex-drug complex. Journal of the American Chemical Society, 125 (9). pp. 4066-4067. 10.1021/ja0297988.

Keppler, M.D., James, P.L., Neidle, S., Brown, T. and Fox, K.R. (2003) DNA sequence specificity of triplex-binding ligands. European Journal of Biochemistry, 270 (24). pp. 4982-4992. 10.1046/j.1432-1033.2003.03901.x.

Neidle, S., Schneider, B. and Berman, H.M. (2003) Fundamentals of DNA and RNA structure. Methods of Biochemical Analysis, 44 . pp. 41-73.

Haider, S.M., Parkinson, G.N. and Neidle, S. (2003) Structure of a G-quadruplex–Ligand Complex. Journal of Molecular Biology, 326 (1). pp. 117-125. 10.1016/S0022-2836(02)01354-2.

2002

Parkinson, G.N., Lee, M.P.H. and Neidle, S. (2002) Crystal structure of parallel quadruplexes from human telomeric DNA. Nature, 417 (6891). pp. 876-880. 10.1038/nature755.

1994

Jenkins, T.C., Hurley, L.H., Neidle, S. and Thurston, D.E. (1994) Structure of a Covalent DNA Minor Groove Adduct with a Pyrrolobenzodiazepine Dimer: Evidence for Sequence-Specific Interstrand Crosslinking. Journal of Medicinal Chemistry, 37 (26). pp. 4529-4537. 10.1021/jm00052a012.

1992

Bose, D.S., Thompson, A.S., Smellie, M., Berardini, M.D., Hartley, J.A., Jenkins, T.C., Neidle, S. and Thurston, D.E. (1992) Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers. Journal of the Chemical Society, Chemical Communications (20). p. 1518. 10.1039/C39920001518.

1990

Jones, G.B., Davey, C.L., Jenkins, T.C., Kamal, A., Kneale, G.G., Neidle, S., Webster, G.D. and Thurston, D.E. (1990) The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA. Anti-cancer Drug Design, 5 (3). pp. 249-264.

This list was generated on Fri Apr 18 23:18:52 2014 BST.