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Number of items: 34.


Falodun, A., Sheng-Xiang, Q., Parkinson, G.N. and Gibbons, S. (2012) Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia. Pharmaceutical Chemistry Journal, 45 (10). pp. 636-639. 10.1007/s11094-012-0693-4.

Campbell, N.H., Karim, N.H.A., Parkinson, G.N., Gunaratnam, M., Petrucci, V., Todd, A.K., Vilar, R. and Neidle, S. (2012) Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes. Journal of Medicinal Chemistry, 55 (1). pp. 209-222. 10.1021/jm201140v.

Collie, G.W., Promontorio, R., Hampel, S.M., Micco, M., Neidle, S. and Parkinson, G.N. (2012) Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands. Journal of the American Chemical Society, 134 (5). pp. 2723-2731. 10.1021/ja2102423.


Haider, S.M., Neidle, S. and Parkinson, G.N. (2011) A structural analysis of G-quadruplex/ligand interactions. Biochimie, 93 (8). pp. 1239-1251. 10.1016/j.biochi.2011.05.012.

Buanz, A.B., Parkinson, G.N. and Gaisford, S. (2011) Characterization of Carbamazepine-Nicatinamide Cocrystal Polymorphs with Rapid Heating DSC and XRPD. Crystal Growth & Design, 11 (4). p. 1177. 10.1021/cg101377u.

Collie, G.W., Sparapani, S., Parkinson, G.N. and Neidle, S. (2011) Structural basis of telomeric RNA quadruplex-acridine ligand recognition. Journal of the American Chemical Society, 133 (8). pp. 2721-2728. 10.1021/ja109767y.

Collie, G.W. and Parkinson, G.N. (2011) The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chemical Society Reviews . 10.1039/C1CS15067G .


Collie, G.W., Parkinson, G.N., Neidle, S., Rosu, F., De Pauw, E. and Gabelica, V. (2010) Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. Journal of the American Chemical Society . 10.1021/ja100345z.

Collie, G.W., Haider, S.M., Neidle, S. and Parkinson, G.N. (2010) A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Research . 10.1093/nar/gkq259 .

Leonard, P.G., Parkinson, G.N., Gor, J., Perkins, S.J. and Ladbury, J.E. (2010) The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein. Acta Crystallographica Section F - Structural Biology and Crystallization Communications, 66 . pp. 421-425. 10.1107/S1744309110004574.

Arold, S.T., Leonard, P.G., Parkinson, G.N. and Ladbury, J.E. (2010) H-NS forms a superhelical protein scaffold for DNA condensation. Proceedings of the National Academy of Sciences of the United States of America, 107 (36). pp. 15728-15732. 10.1073/pnas.1006966107.


Campbell, N.H., Patel, M., Tofa, A., Ghosh, R., Parkinson, G.N. and Neidle, S. (2009) Selectivity in ligand recognition of G-quadruplex loops. Biochemistry, 48 (1). pp. 1675-1680. 10.1021/bi802233v.

Collie, G.W., Reszka, A.P., Haider, S.M., Gabelica, V., Parkinson, G.N. and Neidle, S. (2009) Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chemical Communications, 48 . pp. 7482-7484. 10.1039/b901889a.


Drewe, W.C., Nanjunda, R., Gunaratnam, M., Beltran, M., Parkinson, G.N., Reszka, A.P., Wilson, W.D. and Neidle, S. (2008) Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. Journal of Medicinal Chemistry, 51 (24). pp. 7751-7767. 10.1021/jm801245v.

Neidle, S. and Parkinson, G.N. (2008) Quadruplex DNA crystal structures and drug design. Biochimie, 90 (8). pp. 1184-1190. 10.1016/j.biochi.2008.03.003.

Haider, S.M., Parkinson, G.N. and Neidle, S. (2008) Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophysical Journal, 95 (1). pp. 296-311. 10.1529/biophysj.107.120501.

Zagotto, G., Sissi, C., Moro, S., Del Ben, D., Parkinson, G.N., Fox, S., Neidle, S. and Palumbo, M. (2008) Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorganic & Medicinal Chemistry, 16 (1). pp. 354-361. 10.1016/j.bmc.2007.09.040.

Parkinson, G.N., Vines, D., Driscoll, P.C. and Djordjevic, S. (2008) Crystal structures of PI3K-C2α PX domain indicate conformational change associated with ligand binding. BMC Structural Biology, 8 (1). p. 13. 10.1186/1472-6807-8-13.

Campbell, N.H., Parkinson, G.N., Reszka, A.P. and Neidle, S. (2008) Structural basis of DNA quadruplex recognition by an acridine drug. Journal of the American Chemical Society, 130 (21). pp. 6722-6724. 10.1021/ja8016973.

Parkinson, G.N., Cuenca, F. and Neidle, S. (2008) Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. Journal of Molecular Biology, 381 (5). pp. 1145-1156. 10.1016/j.jmb.2008.06.022.


Lee, M.P., Parkinson, G.N., Hazel, P. and Neidle, S. (2007) Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. Journal of the American Chemical Society, 129 (33). pp. 10106-10107. 10.1021/ja0740869.

Parkinson, G.N., Ghosh, R. and Neidle, S. (2007) Structural basis for binding of porphyrin to human telomeres. Biochemistry, 46 (9). pp. 2390-2397. 10.1021/bi062244n.

Campbell, N.H. and Parkinson, G.N. (2007) Crystallographic studies of quadruplex nucleic acids. Methods, 43 (4). pp. 252-263. 10.1016/j.ymeth.2007.08.005.

Todd, A.K., Haider, S.M., Parkinson, G.N. and Neidle, S. (2007) Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Research, 35 (17). pp. 5799-5808. 10.1093/nar/gkm609.


Burge, Sarah, Parkinson, G.N., Hazel, P., Todd, A.K. and Neidle, S. (2006) Quadruplex DNA: sequence, topology and structure. Nucleic Acids Research, 34 (19). pp. 5402-5415. 10.1093/nar/gkl655.

Hazel, P., Parkinson, G.N. and Neidle, S. (2006) Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Research, 34 (7). pp. 2117-2127. 10.1093/nar/gkl182 .

Campbell, N.H., Evans, D.H., Lee, M.P.H., Parkinson, G.N. and Neidle, S. (2006) Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure. Bioorganic and Medicinal Chemistry Letters, 16 (1). pp. 15-19. 10.1016/j.bmcl.2005.10.036.

Hazel, P., Parkinson, G.N. and Neidle, S. (2006) Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. Journal of the American Chemical Society, 128 . pp. 5480-5487. 10.1021/ja058577+.


Miao, Y., Lee, M.P., Parkinson, G.N., Batista-Parra, A., Ismail, M.A., Neidle, S., Boykin, D.W. and Wilson, W.D. (2005) Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry, 44 (45). pp. 14701-14708. 10.1016/j.bpc.2006.06.006.

Rankin, S., Reszka, A.P., Huppert, J., Zloh, M., Parkinson, G.N., Todd, A.K., Ladame, S., Balasubramanian, S. and Neidle, S. (2005) Putative DNA quadruplex formation within the human c-kit oncogene. Journal of the American Chemical Society, 127 . pp. 10584-10589. 10.1021/ja050823u.


Johansson, E., Parkinson, G.N., Denny, W.A. and Neidle, S. (2003) Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the nhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. Journal of Medicinal Chemistry, 46 (19). pp. 4009-4020. 10.1021/jm030843b.

Parkinson, G.N. and Neidle, S. (2003) The structure of telomeric DNA. Current Opinion in Structural Biology, 13 (3). pp. 275-283. 10.1016/S0959-440X(03)00072-1.

Haider, S.M., Parkinson, G.N. and Neidle, S. (2003) Structure of a G-quadruplex–Ligand Complex. Journal of Molecular Biology, 326 (1). pp. 117-125. 10.1016/S0022-2836(02)01354-2.


Parkinson, G.N., Lee, M.P.H. and Neidle, S. (2002) Crystal structure of parallel quadruplexes from human telomeric DNA. Nature, 417 (6891). pp. 876-880. 10.1038/nature755.

This list was generated on Fri May 29 07:21:05 2015 BST.