Browse by Person

Article

Anderson, J.C., McCarthy, R.A., Paulin, S. and Taylor, P.W. (2011) Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (−)-epicatechin gallate. Bioorganic & Medicinal Chemistry Letters, 21 (23). pp. 6996-7000. 10.1016/j.bmcl.2011.09.116.

Putcha, L., Taylor, P.W. and Boyd, J.L. (2011) Biopharmaceutical challenges of therapeutics in space: formulation and packaging considerations. Therapeutic Delivery, 2 (11). pp. 1373-1376. 10.4155/tde.11.115.

Rosado, H., O’Neill, A.J., Blake, K., Walther, M., Long, P.F., Hinds, J. and Taylor, P.W. (2011) Rotating wall vessel alters protein secretion and global gene expression by Staphylococcus aureus. International Journal of Astrobiology, 11 (2). pp. 71-81.

Rosado, H., Rahman, K.M., Feuerbaum, E-A., Hinds, J., Thurston, D.E. and Taylor, P.W. (2011) The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 66 (5). pp. 985-996. 10.1093/jac/dkr044.

Zelmer, A., Martin, M.J., Gundogdu, O., Birchenough, G., Lever, R., Wren, B.W., Luzio, J.P. and Taylor, P.W. (2010) Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1. Microbiology, 156 (7). pp. 2205-2215. 10.1099/mic.0.036145-0.

Bernal, P., Lemaire, S., Pinho, M.G., Mobashery, S., Hinds, J. and Taylor, P.W. (2010) Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2A-mediated β-lactam resistance by delocalizing PBP2. Journal of Biological Chemistry, 285 . pp. 24055-24065. 10.1074/jbc.M110.114793 .

Glonti, T., Chanishvili, N. and Taylor, P.W. (2010) Bacteriophage-derived enzyme that depolymerizes the alginic acid capsule associated with cystic fibrosis isolates of Pseudomonas aeruginosa. Journal of Applied Microbiology, 108 (2). pp. 695-702. 10.1111/j.1365-2672.2009.04469.x.

Glonti, T., Chanishvili, N. and Taylor, P.W. (2010) Bacteriophage-derived enzyme that depolymerizes the alginic acid capsule associated with cystic fibrosis isolates ofPseudomonas aeruginosa. Journal of Applied Microbiology, 108 (2). pp. 695-702. 10.1111/j.1365-2672.2009.04469.x.

Bernal, P., Lemaire, S., Pinho, M.G., Mobashery, S., Hinds, J. and Taylor, P.W. (2010) Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. Journal of Biological Chemistry, 285 (31). pp. 24055-24065. 10.1074/jbc.M110.114793.

Rosado, H., Doyle, M., Hinds, J. and Taylor, P.W. (2010) Low-shear modelled microgravity alters expression of virulence determinants of Staphylococcus aureus. Acta Astronautica, 66 (3-4). pp. 408-413. 10.1016/j.actaastro.2009.06.007 .

Taylor, P.W., Arnet, I., Fischer, A. and Simpson, I.N. (2010) Pharmaceutical quality of nine generic orlistat products compared with Xenical(r). Obesity facts, 3 (4). pp. 231-237. 10.1159/000319450.

Doyle, M., Feuerbaum, E-A., Fox, K.R., Hinds, J., Thurston, D.E. and Taylor, P.W. (2009) Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove binding cross-linking pyrrolobenzodiazepine dimer. Journal of Antimicrobial Chemotherapy, 64 (5). pp. 949-959. 10.1093/jac/dkp325 .

Bernal, P., Zloh, M. and Taylor, P.W. (2009) Disruption of D-alanyl esterification of Staphylococcus aureus cell wall teichoic acid by the beta-lactam-resistance modifier(-)-epicatechin gallate. Journal of Antimicrobial Chemotherapy, 63 (6). pp. 1156-1162. 10.1093/jac/dkp094.

Kim, C.E., Griffiths, W.J. and Taylor, P.W. (2009) Components derived from Pelargonium stimulate macrophage killing of Mycobacterium species. Journal of Applied Microbiology, 106 . pp. 1184-1193. 10.1111/j.1365-2672.2008.04085.x.

Cushnie, T.P., Taylor, P.W., Nagaoka, Y., Uesato, S., Hara, Y. and Lamb, A.J. (2008) Investigation of the antibacterial activity of 3-O-octanoyl-(-)-epicatechin. Journal of Applied Microbiology, 105 (5). pp. 1461-1469. 10.1111/j.1365-2672.2008.03881.x.

Zelmer, A., Bowen, M., Jokilammi, A., Finne, J., Luzio, J.P. and Taylor, P.W. (2008) Differential expression of the polysialyl capsule during blood-to-brain transit of neuropathogenic Escherichia coli K1. Microbiology, 154 (8). pp. 2522-2532. 10.1099/mic.0.2008/017988-0.

Taylor, P.W. (2008) An anti-bac alert. Public Service Review: Health, 18 (25 February).

Shah, S., Stapleton, P.D. and Taylor, P.W. (2008) The polyphenol (-)- epicatechin gallate disrupts the secretion of virulence-related proteins by Staphylococcus aureus. Letters In Applied Microbiology, 46 (2). pp. 181-185. 10.1111/j.1472-765X.2007.02296.x.

Stapleton, P.D., Shah, S., Ehlert, K., Hara, Y. and Taylor, P.W. (2007) Effect of the beta-lactam-resistance modifier(-)-epicatechin gallate on the architecture of the cell wall of Staphylococcus aureus. Microbiology, 153 . pp. 2093-2103. 10.1099/mic.0.2007/007807-0.

Hadjivassileva, T., Stapleton, P.D., Thurston, D.E. and Taylor, P.W. (2007) Interactions of pyrrolobenzodiazepine dimers and duplex DNA from methicillin-resistant Staphylococcus aureus. International Journal of Antimicrobial Agents, 29 (6). pp. 672-678. 10.1016/j.ijantimicag.2007.01.005 .

Cushnie, T.P., Hamilton, V.E., Chapman, D.G., Taylor, P.W. and Lamb, A.J. (2007) Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin. Journal of Applied Microbiology, 103 (4). pp. 1562-1567. 10.1111/j.1365-2672.2007.03393.x.

Stapleton, P.D., Gettert, J. and Taylor, P.W. (2006) Epicatechin gallate, a component of green tea, reduces hatotolerance in Staphylococcus aureus. International Journal of Food Microbiology, 111 (3). pp. 276-279. 10.1016/j.ijfoodmicro.2006.06.005 .

Taylor, P.W. and Brown, M. (2006) Advancing phamacy education and research through Maplethorpe fellowships. Pharmaceutical Journal, 276 . pp. 208-213.

Rosado, H., Stapleton, P.D. and Taylor, P.W. (2006) Effect of simulated microgravity on the virulence properties of the opportunistic bacterial pathogen Staphylococcus aureus. Proceedings of the 57th International Astronautical federation Congress .

Taylor, P.W. (2006) Pharmaceutical quality of generic isotretinoin products, compared to Roaccutane. Current Medical Research and Opinion, 22 (3). pp. 603-615. 10.1185/030079906X96326.

Stapleton, P.D., Shah, S., Hara, Y. and Taylor, P.W. (2006) Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacilin by non-galloylated catechins. Antimicrobial Agents and Chemotherapy, 50 . pp. 752-755. 10.1128/AAC.50.2.752-755.2006.

Taylor, P.W. (2005) Towards rational treatment of bacterial infections during extended space flight. International Journal of Antimicrobial Agents, 26 (3). pp. 183-187. 10.1016/j.ijantimicag.2005.06.002.

Anderson, J.C., Headley, C., Stapleton, P.D. and Taylor, P.W. (2005) Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues and their modulation of beta-lactam resistance in Staphylococcus aureus. Bioorganic and Medicinal Chemistry Letters, 15 (10). pp. 2633-2635. 10.1016/j.bmcl.2005.03.063.

Taylor, P.W., Hamilton-Miller, J.M.T. and Stapleton, P.D. (2005) Antimicrobial properties of green tea catechins. Food Science and Technology Bulletin, 2 . pp. 71-81.

Anderson, J.C., Headley, C., Stapleton, P.D. and Taylor, P.W. (2005) Asymmetric total synthesis of B-ring modified (-)-epicatechin gallate analogues and their modulation of beta-lactam resistance in Staphylococcus aureus. Tetrahedron, 61 . pp. 7703-7711. 10.1016/j.tet.2005.05.086.

Rowland, R.E.S., Taylor, P.W. and Florence, A.T. (2005) Attachment, uptake and transport of nanoparticles coated with an internalin A fragment through a Caco-2 monolayer. Drug Delivery Science and Technology, 15 . pp. 313-317.

Hadjivassileva, T., Stapleton, P.D., Thurston, D.E. and Taylor, P.W. (2005) Pyrrolobenzodiazepine dimers: novel sequence-selective, DNA-interactive, cross-linking agents with activity against Gram-positive bacteria. Journal of Antimicrobial Chemotherapy, 56 (3). pp. 513-518. 10.1093/jac/dki256.

Taylor, P.W., Maalim, S. and Coleman, S. (2005) The strange story of Umckaloabo. Pharmaceutical Journal, 275 . pp. 790-792.

Mushtaq, N., Redpath, M.B., Luzio, J.P. and Taylor, P.W. (2005) Treatment of experimental Escherichia coli infecton with recombinant bacteriophage-derived capsule depolymerase. Journal of Antimicrobial Chemotherapy, 56 . pp. 160-165. 10.1093/jac/dki177.

Stapleton, P.D., Shah, S., Hamilton-Miller, J.M.T., Hara, Y., Nagaoka, Y., Kumagai, A., Uesato, S. and Taylor, P.W. (2004) Anti-Staphylococcus aureus activity and oxacillin resistance modulating capacity of 3-0-actyl-catechins. International Journal of Antimicrobial Agents, 24 (4). pp. 374-380. 10.1016/j.ijantimicag.2004.03.024.

Hitch, G., Pratten, J. and Taylor, P.W. (2004) Isolation of bacteriophages from the oral cavity. Letters In Applied Microbiology, 39 (2). pp. 215-219. 10.1111/j.1472-765X.2004.01565.x.

Seidel, V. and Taylor, P.W. (2004) In vitro activity of extracts and constituents of Pelargonium against rapidly growing mycobacteria. International Journal of Antimicrobial Agents, 23 (6). pp. 613-619. 10.1016/j.ijantimicag.2003.11.008.

Mushtaq, N., Redpath, M.B., Luzio, J.P. and Taylor, P.W. (2004) Prevention and cure of systemic Escherichia coli K1 infection by modification of the bacterial phenotype. Antimicrobial Agents and Chemotherapy, 48 (5). pp. 1503-1508. 10.1128/AAC.48.5.1503-1508.2004.

Taylor, P.W., Stapleton, P.D., Shah, S. and Anderson, J.C. (2004) Modification of staphylococci by catechin gallates. ICOS Proceedings, 2 . pp. 414-417.

Stapleton, P.D., Shah, S., Anderson, J.C., Hara, Y., Hamilton-Miller, J.M.T. and Taylor, P.W. (2004) Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates. International Journal of Antimicrobial Agents, 23 (5). pp. 462-467. 10.1016/j.ijantimicag.2003.09.027.

Taylor, P.W., Seidel, V. and Gillespie, S.H. (2003) "Umckaloabo" - a South African herbal remedy for tuberculosis? Antibiotics Chemotherapy, 7 . pp. 10-11.

Taylor, P.W. (2003) Anti-mycobacterial activity of indigenous South African plants. South African Medical Journal, 93 . pp. 904-907.

Leggate, D.R., Bryant, J.M., Redpath, M.B., Head, D., Taylor, P.W. and Luzio, J.P. (2002) Expression, mutagenesis and kinetic analysis of recombinant K1E endosialidase to define the site of proteolytic processing and the requirement for a specific aspartate residue in catalysis. Molecular Microbiology, 44 (3). pp. 749-760. 10.1046/j.1365-2958.2002.02908.x.

Taylor, P.W. and Stapleton, P.D. (2002) Structural pharmacogenomics: the answer to antimicrobial drug resistance? Drug Discovery Today, 8 (3). pp. 110-111. 10.1016/S1359-6446(02)02591-6.

Hamilton-Miller, J.M.T. and Taylor, P.W. (2002) Antimicrobial activity of Japanese green tea: present position and future prospects. ICOS Proceedings III . pp. 261-263.

Stapleton, P.D. and Taylor, P.W. (2002) Methicillin resistance in staphylococcus aureus: mechanisms and modulation. Science Progress, 85 (1). pp. 57-72.

Taylor, P.W., Stapleton, P.D. and Luzio, J.P. (2002) New ways to treat bacterial infections. Drug Discovery Today, 7 (21). pp. 1086-1091. 10.1016/S1359-6446(02)02498-4.

Brandon, N.J., Bedford, F.K., Connolly, C.N., Couve, A., Kittler, J.T., Hanley, J.G., Jovanovic, J.N., Uren, J., Taylor, P.W., Thomas, P., Smart, T.G. and Moss, S.J. (1999) Synaptic targeting and regulation of GABA(A) receptors. Biochemical Society Transactions, 27 (4). pp. 527-530. 10.1042/bst0270527 .

Book Section

Putcha, L. and Taylor, P.W. (2011) Stability of medications in space: therapeutic implications for extended duration space missions. In: Advances in Engineering Research. Vol. 1. Nova Science, Hauppauge, NY, pp. 221-239. ISBN 978-1612097985.

Taylor, P.W., Bernal, P. and Zelmer, A. (2009) Modification of the bacterial phenotype as an approach to counter the emergence of multidrug-resistant pathogens. In: Antibiotic Resistance: Causes and Risk Factors, Mechanisms and Alternatives. Nova Science Publishers, Hauppauge, New York, USA, pp. 43-78. ISBN 978-1-60741-623-4.

Taylor, P.W. and Rosado, H. (2008) Manned Missions to Mars: The Likely Impact of Microbial Infection. In: Planet Mars Research Focus. Nova Science, New York, USA, p. 165. ISBN 978-1-60021-826-2.

Rosado, H., Doyle, M., Hinds, J. and Taylor, P.W. (2008) Abstract: Low-shear modelled microgravity alters expression of virulence determinants by Staphylococcus aureus. In: Proceedings of the 59th International Astronautical Federation Congress IAC-08. IAC, A1 7.-A2 7.5.

Patent

School of Pharmacy (2005) Compositions and methods of sensitizing methicillin resistant Staphylococcus aureus to oxacillin. 100799.0017.

School of Pharmacy (2004) Pyrrolobenzodiazepines. RJWL/LP6165765.

School of Pharmacy (2004) Compounds for use in the treatment of infection. HMJ03770GB.

School of Pharmacy (2003) Antimicrobial compositions and methods of use. 100799.0003.