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Number of items: 91.

Article

Rahman, K.M., Tizkova, K., Reszka, A.P., Neidle, S. and Thurston, D.E. (2012) Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. Bioorganic and Medicinal Chemistry Letters, 22 (8). pp. 3006-3010. 10.1016/j.bmcl.2012.02.020.

Guimaraes, A.M.R., Thurston, D.E. and Yang, M. (2011) Abstract: Glycosylation of novobiocin leads to novel antibiotics and anticancer drugs. Abstract of Papers of the American Chemical Society, 241 (102-CARB).

Hartley, J.A., Hamaguchi, A., Suggitt, M., Gregson, S.J., Thurston, D.E. and Howard, P.W. (2011) DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057. Investigational New Drugs . 10.1007/s10637-011-9647-z.

Rahman, K.M., James, C.H. and Thurston, D.E. (2011) Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers. Nucleic Acids Research, 39 (13). pp. 5800-5812. 10.1093/nar/gkr122.

Brucoli, F., Hawkins, R.M., James, C.H., Wells, G., Jenkins, T.C., Ellis, T., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. Bioorganic & Medicinal Chemistry Letters, 21 (12). pp. 3780-3783. 10.1016/j.bmcl.2011.04.054.

Rahman, K.M., James, C.H., Bui, T.T.T., Drake, A.F. and Thurston, D.E. (2011) Observation of a Single-Stranded DNA/Pyrrolobenzodiazepine Adduct. Journal of the American Chemical Society, 133 (48). pp. 19376-19385. 10.1021/ja205395r.

Rahman, K.M., James, C.H. and Thurston, D.E. (2011) Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy. Organic & Biomolecular Chemistry, 9 (5). pp. 1632-1641. 10.1039/c0ob00762e.

Bendiabdellah, Y., Villanueva-Margalef, I., Misale, A., Nahar, K., Haque, M.R., Thurston, D.E. and Zinzalla, G. (2011) One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones. Synthesis, 2011 (14). pp. 2321-2333. 10.1055/s-0030-1260073.

Reid, J.M., Buhrow, S.A., Kuffel, M J., Jiang, L., Spanswick, V.J., Hartley, J.A., Thurston, D.E., Tomaszewski, J.E. and Ames, M.M. (2011) Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats. Cancer Chemotherapy and Pharmacology, 68 (3). pp. 777-786. 10.1007/s00280-010-1517-4.

Antonow, D. and Thurston, D.E. (2011) Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs). Chemical Reviews, 111 (4). pp. 2815-2864. 10.1021/cr100120f.

Rosado, H., Rahman, K.M., Feuerbaum, E-A., Hinds, J., Thurston, D.E. and Taylor, P.W. (2011) The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 66 (5). pp. 985-996. 10.1093/jac/dkr044.

Antonow, D., Marrafa, T., Dawood, I., Ahmed, T., Haque, M.R., Thurston, D.E. and Zinzalla, G. (2010) Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O. Chemical Communications (13). 2289-2291`. 10.1039/b924333j.

Brucoli, F., Hawkins, R.M., Wells, G., Jenkins, T.C., Ellis, T., Kotecha, M., Hochhauser, D., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2010) 526 A potent PBD-heterocyclic polyamide conjugate targeting an ICB2 transcription factor binding site. European Journal of Cancer Supplements, 8 (7). p. 168. 10.1016/S1359-6349(10)72233-3.

Zinzalla, G., Haque, M.R., Basu, B Piku, Anderson, J., Kaye, S.L., Haider, S.M., Hasan, F., Antonow, D., Essex, S., Rahman, K.M., Palmer, J., Morgenstern, D., Wilderspin, A.F., Neidle, S. and Thurston, D.E. (2010) A novel small-molecule inhibitor of IL-6 signalling. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 7029-32. 10.1016/j.bmcl.2010.09.117.

Rahman, K.M., Vassoler, H., James, C.H. and Thurston, D.E. (2010) DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents. ACS Medicinal Chemistry Letters, 1 (8). pp. 427-432. 10.1021/ml100131b.

Kaliszczak, M., Antonow, D., Patel, Katan I., Howard, P., Jodrell, D.I., Thurston, D.E. and Guichard, S.M. (2010) Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters. The AAPS Journal, 12 (4). pp. 617-627. doi:10.1208/s12248-010-9225-x.

Antonow, D., Kaliszczak, M., Kang, G.D., Coffils, M.J., Tiberghien, A.C., Cooper, N., Barata, T.S., Heidelberger, S., James, C.H., Zloh, M., Jenkins, T.C., Reszka, A.P., Neidle, S., Guichard, S.M., Jodrell, D.I., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2010) Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents. Journal of Medicinal Chemistry, 53 (7). pp. 2927-2941. 10.1021/jm901722v.

Howard, P.W., Chen, Z., Gregson, S.J., Masterson, L., Tiberghien, A.C., Cooper, N., Fang, M., Coffils, M.J., Hartley, J.A. and Thurston, D.E. (2009) Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate. Biorganic and Medicinal Chemistry Letters, 19 (22). pp. 6463-6466. 10.1016/j.bmcl.2009.09.012.

Doyle, M., Feuerbaum, E-A., Fox, K.R., Hinds, J., Thurston, D.E. and Taylor, P.W. (2009) Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove binding cross-linking pyrrolobenzodiazepine dimer. Journal of Antimicrobial Chemotherapy, 64 (5). pp. 949-959. 10.1093/jac/dkp325 .

Rahman, K.M., Reszka, A.P., Gunaratnam, M., Haider, S.M., Howard, P.W., Fox, K.R., Neidle, S. and Thurston, D.E. (2009) Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Chemical Communications, 27 . pp. 4097-4099. 10.1039/b902359c.

Rahman, K.M. and Thurston, D.E. (2009) Effect of microwave irradiation on covalent ligand-DNA interactions. Chemical Communications (20). pp. 2875-2877. 10.1039/b902357g.

Brucoli, F., Howard, P.W. and Thurston, D.E. (2009) Efficient solid-phase synthesis of a library of distamycin analogs containing novel biaryl motifs on synphase lanterns. Journal of Combinatorial Chemistry, 11 (4). pp. 576-586. 10.1021/cc900009r.

Rahman, K.M., Narayanaswamy, M., James, C.H., Howard, P.W. and Thurston, D.E. (2009) Observation of a dynamic equilibrium between DNA hairpin and duplex forms of covalent adducts of a minor groove binding agent. Chemical Communications . pp. 227-229. 10.1039/b816163a.

Zinzalla, G. and Thurston, D.E. (2009) Targeting protein-protein interactions for therapeutic intervention: a challenge for the future. Future Medicinal Chemistry, 1 (1). pp. 65-93. 10.4155/fmc.09.12.

Rahman, K.M., Thompson, A.S., James, C.H., Narayanaswamy, M. and Thurston, D.E. (2009) The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links. Journal of the American Chemical Society, 131 (38). pp. 13756-13766. 10.1021/ja902986x.

Ojima, I. and Thurston, D.E. (2009) Welcome to Future Medicinal Chemistry. Future Medicinal Chemistry, 1 (1). pp. 1-2. 10.4155/FMC.09.14.

Narayanaswamy, M., Griffiths, W.J., Howard, P.W. and Thurston, D.E. (2008) An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences. Analytical Biochemistry, 374 (1). pp. 173-181. 10.1016/j.ab.2007.11.018.

Kotecha, M., Kluza, J., Wells, G., O'Hare, C.C., Forni, C., Mantovani, R., Howard, P.W., Morris, P., Thurston, D.E., Hartley, J.A. and Hochhauser, D. (2008) Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78. Molecular Cancer Therapeutics, 7 . pp. 1319-1328. 10.1158/1535-7163.MCT-07-0475.

Tiberghien, A.C., Evans, David A., Kiakos, K., Martin, C.R.H., Hartley, J.A., Thurston, D.E. and Howard, P.W. (2008) An asymmetric C8/C8'-tripyrrole-llinked sequence-selective Pyrrolo[2,1-c]]1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs. Bioorganic and Medicinal Chemistry Letters, 18 (6). pp. 2073-2077. 10.1016/j.bmcl.2008.01.096.

Wells, G., Suggitt, M., Stephenson, M., Baig, M.A.H., Howard, P.W., Loadman, P.M., Hartley, J.A., Jenkins, T.J. and Thurston, D.E. (2008) Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization. Bioorganic and Medicinal Chemistry Letters, 18 . pp. 2147-2151. 10.1016/j.bmcl.2008.01.083 .

Aird, R.E., Thomson, M., Macpherson, J.S., Thurston, D.E., Jodrell, D.I. and Guichard, S.M. (2008) ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136. Pharmacogenomics Journal, 8 (4). pp. 289-296. 10.1038/sj.tpj.6500465.

Antonow, D., Barata, T.S., Jenkins, T.C., Parkinson, D.N., Howard, P.W., Thurston, D.E. and Zloh, M. (2008) Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization. Biochemistry, 47 (45). pp. 11818-11829. 10.1021/bi801225q.

Patel, A.V., Blunden, G., Cary, P.D., Opletal, L., Berankova, M., Karu, K., Thurston, D.E. and Pour, M. (2008) T-cadinol nerolidol ether from Schisandra chinensis. Natural Product Communications, 3 . pp. 1453-1456.

Hadjivassileva, T., Stapleton, P.D., Thurston, D.E. and Taylor, P.W. (2007) Interactions of pyrrolobenzodiazepine dimers and duplex DNA from methicillin-resistant Staphylococcus aureus. International Journal of Antimicrobial Agents, 29 (6). pp. 672-678. 10.1016/j.ijantimicag.2007.01.005 .

Burger, A.M., Loadman, P.M., Thurston, D.E., Schultz, R., Fiebig, H.H. and Bibby, M.C. (2007) Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119). Journal of Chemotherapy, 19 (1). pp. 66-78.

Pepper, C., Lowe, H., Fegan, C., Thurieau, C., Thurston, D.E., Hartley, J.A. and Delavault, P. (2007) Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells. British Journal of Cancer, 97 (2). pp. 253-259. 10.1038/sj.bjc.6603853.

Antonow, D., Cooper, N., Howard, P.W. and Thurston, D.E. (2007) Parallel Synthesis of a Novel C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Library. Journal of Combinatorial Chemistry, 9 (3). pp. 437-445. 10.1021/cc0601332.

Antonow, D., Jenkins, T.C., Howard, P.W. and Thurston, D.E. (2007) Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: Effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding. Bioorganic & Medicinal Chemistry Letters, 15 (8). pp. 3041-3053. 10.1016/j.bmc.2007.01.054.

Wells, G., Martin, C.R.H., Howard, P.W., Sands, Z.A., Laughton, C.A., Tiberghien, A.C., Woo, C.-K., Masterson, L., Stephenson, M.J., Hartley, J.A., Jenkins, T.C., Shnyder, S.D., Loadman, P.M., Waring, M.J. and Thurston, D.E. (2006) Design, synthesis and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates. Journal of Medicinal Chemistry, 49 (18). pp. 5442-5461. 10.1021/jm051199z .

Masterson, L.A., Spanswick, V.J., Hartley, J.A., Begent, R.H., Howard, P.W. and Thurston, D.E. (2006) Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy. Bioorganic and Medicinal Chemistry Letters, 16 (2). pp. 252-256. 10.1016/j.bmcl.2005.10.017.

Arnould, S., Spanswick, V.J., Macpherson, J.S., Hartley, J.A., Thurston, D.E., Jodrell, D.I. and Guichard, S.M. (2006) Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling. Molecular Cancer Therapeutics, 5 (6). pp. 1602-1609. 10.1158/1535-7163.MCT-06-0018.

Marín, D., Soler, L. and Thurston, D.E. (2006) Voltammetric studies of the interaction of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomers and dimers with DNA. Journal of Electroanalytical Chemistry, 593 (1-2). pp. 241-246. 10.1016/j.jelechem.2006.05.015.

Neidle, S. and Thurston, D.E. (2005) The role of chemical sciences in 21st century cancer drug discovery. Discovery Medicine, 5 (29). pp. 450-454.

Neidle, S. and Thurston, D.E. (2005) Chemical approaches to the discovery and development of cancer therapies. Nature Reviews Cancer, 5 (4). pp. 285-296. 10.1038/nrc1587.

Tsotinis, A., Vlachou, M., Zouroudis, S., Jeney, A., Timar, F., Thurston, D.E. and Roussakis, C. (2005) A Facile Synthesis of C2-Substituted Pyrrolo[2,3-f]quinolines with Cytotoxic Activity. Letters in Drug Design and Discovery, 2 (3). pp. 189-192. 10.2174/1570180053765075.

Cheung, A., Struble, E., He, J., Yang, C., Wang, E., Thurston, D.E. and Liu, P. (2005) Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501). Journal of Chromatography B, 822 (1-2). pp. 10-20. 10.1016/j.jchromb.2005.04.027.

Guichard, S.M., Macpherson, J.S., Thurston, D.E. and Jodrell, D.I. (2005) Influence of P-glycoprotein expression on cytotoxicity and antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136. European Journal of Cancer, 41 (12). p. 1811. 10.1016/j.ejca.2005.04.026.

Hadjivassileva, T., Stapleton, P.D., Thurston, D.E. and Taylor, P.W. (2005) Pyrrolobenzodiazepine dimers: novel sequence-selective, DNA-interactive, cross-linking agents with activity against Gram-positive bacteria. Journal of Antimicrobial Chemotherapy, 56 (3). pp. 513-518. 10.1093/jac/dki256.

Martin, C., Ellis, T., McGurk, C.J., Jenkins, T.C., Hartley, J.A., Waring, M.J. and Thurston, D.E. (2005) Sequence-Selective Interaction of the Minor-Groove Interstrand Cross-Linking Agent SJG-136 with Naked and Cellular DNA:  Footprinting and Enzyme Inhibition Studies†. Biochemistry, 44 (11). pp. 4135-4147. /10.1021/bi0479813.

Clingen, P.H., De Silva, I.U., McHugh, P.J., Ghadessy, F.J., Tilby, M.J., Thurston, D.E. and Hartley, J.A. (2005) The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136. Nucleic Acids Research, 33 (10). pp. 3283-3291. 10.1093/nar/gki639.

Chen, Z., Gregson, S.J., Howard, P.W. and Thurston, D.E. (2004) A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents. Bioorganic & Medicinal Chemistry Letters, 14 (6). pp. 1547-1549. 10.1016/j.bmcl.2003.12.094.

Gregson, S.J., Howard, P.W., Gullick, D.R., Hamaguchi, A., Corcoran, K.E, Brooks, N.A., Hartley, J.A., Jenkins, T.C., Patel, S., Guille, M.J. and Thurston, D.E. (2004) Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers. Journal of Medicinal Chemistry, 47 (5). pp. 1161-1174. 10.1021/jm030897l.

Wilkinson, G.P., Taylor, J.P., Shnyder, S.D., Cooper, P., Howard, P.W., Thurston, D.E., Jenkins, T.C. and Loadman, P.M. (2004) Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent. Investigational New Drugs, 22 (3). pp. 231-240. doi:10.1023/B:DRUG.0000026249.97007.60.

Hartley, J.A., Spanswick, V.J., Brooks, N., Clingen, P.H., McHugh, P.J., Hochhauser, D., Pedley, R.B., Kelland, L.R., Alley, M.C., Schultz, R., Hollingshead, M.G., Schweikart, K.M., Tomaszewski, J.E., Sausville, E.A., Gregson, S.J., Howard, P.W. and Thurston, D.E. (2004) SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity. Cancer research, 64 (18). pp. 6693-6699. 10.1158/0008-5472.CAN-03-2941.

Alley, M.C., Hollingshead, M.G., Pacula-Cox, C.M., Waud, W.R., Hartley, J.A., Howard, P.W., Gregson, S.J., Thurston, D.E. and Sausville, E.A. (2004) SJG-136 (NSC 694501), A Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity: Part 2: Efficacy Evaluations. Cancer Research, 64 (18). pp. 6700-6706. 10.1158/0008-5472.CAN-03-2942.

Masterson, L.A., Croker, S.J., Jenkins, T.C., Howard, P.W. and Thurston, D.E. (2004) Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates. Bioorganic & Medicinal Chemistry Letters, 14 (4). pp. 901-964. 10.1016/j.bmcl.2003.12.017.

Pepper, C.J., Hambly, R.M., Fegan, C.D., Delavault, P. and Thurston, D.E. (2004) The Novel Sequence-Specific DNA Cross-Linking Agent SJG-136 (NSC 694501) Has Potent and Selective In vitro Cytotoxicity in Human B-Cell Chronic Lymphocytic Leukemia Cells with Evidence of a p53-Independent Mechanism of Cell Kill. Cancer Research, 64 (18). pp. 6750-6755. 10.1158/0008-5472.CAN-04-1713.

Tsotinis, A., Vlachou, M., Kiakos, K., Hartley, J.A. and Thurston, D.E. (2003) Design and synthesis of two cytotoxic analogs of the novel pyrrolo[1′,2′:1,2][1,4]diazepin [7,6-b]indol-5(6h)-one nucleus. Chemistry Letters, 32 (6). pp. 512-513. 10.1246/cl.2003.512.

Smellie, M., Bose, D.S., Thompson, A.S., Jenkins, T.C., Hartley, J.A. and Thurston, D.E. (2003) Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemistry, 42 (27). pp. 8232-8239. 10.1021/bi034313t.

Kang, G-D., Howard, P.W. and Thurston, D.E. (2003) Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine. Chemical Communications (14). pp. 1688-1689. 10.1039/B303274D.

Tsotinis, A., Vlachou, M., R. Kelland, L. and Thurston, D.E. (2002) A New Ring-Forming Methodology for the Synthesis of Bioactive Pyrroloquinoline Derivatives. Heterocycles, 57 (1). pp. 129-133. 10.3987/COM-01-9373.

Vlachou, M., Tsotinis, A., Kelland, L.R. and Thurston, D.E. (2002) An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines. European Journal of Pharmaceutical Sciences, 17 (3). pp. 139-143. 10.1016/S0928-0987(02)00163-X.

Berry, J.M., Howard, P.W., Kelland, L.R. and Thurston, D.E. (2002) Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug. Bioorganic and Medicinal Chemistry Letters, 12 (10). pp. 1413-1416. 10.1016/S0960-894X(02)00150-6.

Cooper, N., Hagan, D.R., Tiberghien, A., Ademefun, T., Matthews, C.S., Howard, P.W. and Thurston, D.E. (2002) Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents. Chemical Communications (16). pp. 1764-1765. 10.1039/B205136B.

Sagnou, M.J., Howard, P.W., Gregson, S.J., Eno-Amooquaye, E., Burke, P.J. and Thurston, D.E. (2000) Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT. Bioorganic and Medicinal Chemistry Letters, 10 (18). pp. 2083-2086. 10.1016/S0960-894X(00)00404-2.

Gregson, S.J., Howard, P.W., Corcoran, K.E, Barcella, S., Yasin, M.M., Hurst, A.A., Jenkins, T.C., Kelland, L.R. and Thurston, D.E. (2000) Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines. Bioorganic and Medicinal Chemistry Letters, 10 (16). pp. 1845-1847. 10.1016/S0960-894X(00)00351-6.

Gregson, S.J., Howard, P.W., Barcella, S., Nakamya, A., Jenkins, T.C., Kelland, L.R. and Thurston, D.E. (2000) Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines. Bioorganic and Medicinal Chemistry Letters, 10 (16). pp. 1849-1851. 10.1016/S0960-894X(00)00350-4.

Gregson, S.J., Howard, P.W., Thurston, D.E., Jenkins, T.C. and Kelland, L.R. (1999) Synthesis of a novel C2/C2′-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity. Chemical Communications (9). pp. 797-798. 10.1039/A809791G.

Puvvada, M.S., Forrow, S.A., Hartley, J.A., Stephenson, P., Gibson, I., Jenkins, T.C. and Thurston, D.E. (1997) Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines. Biochemistry, 36 (9). pp. 2478-2484. 10.1021/bi952490r.

Fox, K.R., Thurston, D.E., Jenkins, T.C., Varvaresou, A., Tsotinis, A. and Siatra-Papastaikoudi, T. (1996) A novel series of DNA triple helix-binding ligands. Biochemical and Biophysical Research Communications, 224 (3). pp. 717-720. 10.1006/bbrc.1996.1089.

Zioga, G., Howard, P.W., Canfield, L.M., Gescher, A. and Thurston, D.E. (1996) Interaction of the pyrrolobenzodiazepine antitumour agent anthramycin with glutathione: A possible role in metabolism. Pharmaceutical Sciences, 2 (1). pp. 39-42. 10.1111/j.2042-7158.1996.tb00529.x.

Wilson, S.C., Howard, P.W. and Thurston, D.E. (1995) Design and synthesis of a novel epoxide-containing pyrrolo[2,1-c][1,4]benzodiazepine (PBD) via a new cyclization procedure. Tetrahedron Letters, 36 (35). pp. 6333-6336. 10.1016/0040-4039(95)01224-6.

Hafiz, F., Thurston, D.E., Carr, A.M. and Jones, R.W. (1995) The cytotoxicity of anthramycin to mutants of Schizosaccharomyces pombe deficient in DNA damage responses. Biochemical Society Transactions, 23 (2). 331S.

Mountzouris, J.A., Wang, J.J., Thurston, D.E. and Hurley, L.H. (1994) Comparison of a DSB-120 DNA interstrand cross-linked adduct with the corresponding bis-tomaymycin adduct: an example of a successful template-directed approach to drug design based upon the monoalkylating compound tomaymycin. Journal of Medicinal Chemistry, 37 (19). pp. 3132-3140. 10.1021/jm00045a019.

Jenkins, T.C., Hurley, L.H., Neidle, S. and Thurston, D.E. (1994) Structure of a Covalent DNA Minor Groove Adduct with a Pyrrolobenzodiazepine Dimer: Evidence for Sequence-Specific Interstrand Crosslinking. Journal of Medicinal Chemistry, 37 (26). pp. 4529-4537. 10.1021/jm00052a012.

Courtney, S.M. and Thurston, D.E. (1993) A new convenient procedure for the synthesis of pyrrolo[2,1-c][l,4]benzodiazepines. Tetrahedron Letters, 34 (33). pp. 5327-5328. 10.1016/S0040-4039(00)73987-6.

Bose, D.S., Thompson, A.S., Smellie, M., Berardini, M.D., Hartley, J.A., Jenkins, T.C., Neidle, S. and Thurston, D.E. (1992) Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers. Journal of the Chemical Society, Chemical Communications (20). p. 1518. 10.1039/C39920001518.

Subhas Bose, D, Jones, G.B. and Thurston, D.E. (1992) New approaches to pyrrolo[2,1-c][1,4]benzodiazepines: synthesis, DNA-binding and cytotoxicity of DC-81. Tetrahedron, 48 (40). p. 751. 10.1016/S0040-4020(01)88134-5.

Hartley, J.A., Berardini, M.D., Ponti, M., Gibson, N.W., Thompson, A.S., Thurston, D.E., Hoey, B.M. and Butler, J.A. (1991) DNA cross-linking and sequence selectivity of aziridinylbenzoquinones: a unique reaction at 5'-GC-3' sequences with 2,5-diaziridinyl-1,4-benzoquinone upon reduction. Biochemistry, 30 (50). pp. 11719-11724.

Jackson, C.A., Hartley, J.A., Jenkins, T.C., Godfrey, R., Saunders, R. and Thurston, D.E. (1991) N2,N4,N6-tri(hydroxymethyl)-N2,N4,N6-trimethylmelamine (trimelamol) is an efficient DNA cross-linking agent in vitro. Biochemical Pharmacology, 42 (11). pp. 2091-2097. 10.1016/0006-2952(91)90343-4.

Morris, S.J., Thurston, D.E. and Nevell, T.G. (1990) Evaluation of the electrophilicity of DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines by HPLC. Journal of Antibiotics, 43 (10). pp. 1286-1292.

Thurston, D.E., Murty, V.S., Langley, D.R. and Jones, G.B. (1990) O-Debenzylation of a Pyrrolo[2,1-c][1,4]benzodiazepine in the Presence of a Carbinolamine Functionality: Synthesis of DC-81. Synthesis, 1990 (01). pp. 81-84. 10.1055/s-1990-26795.

Thurston, D.E., Jones, G.B. and Davis, M.E. (1990) Synthesis and reactivity of a novel oxazolo[2, 3-c][1,4]benzodiazepine ring system with DNA recognition potential: a new class of anthramycins. Journal of the Chemical Society, Chemical Communications (12). pp. 874-876. 10.1039/C39900000874.

Jones, G.B., Davey, C.L., Jenkins, T.C., Kamal, A., Kneale, G.G., Neidle, S., Webster, G.D. and Thurston, D.E. (1990) The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA. Anti-cancer Drug Design, 5 (3). pp. 249-264.

Kamal, A. and Thurston, D.E. (1989) Reaction of pyrrolo[2,1-c][1,4]benzodiazepine-2,5,11-triones with phosphorus oxychloride. Tetrahedron Letters, 30 (45). pp. 6221-6222. 10.1016/S0040-4039(01)93348-9.

Hurley, L.H., Reck, T., Thurston, D.E., Langley, D.R., Holden, K.G., Hertzberg, R.P., Hoover, J.R., Gallagher, G., Faucette, L.F. and Mong, S.M. (1988) Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds. Chemical Research in Toxicology, 1 (5). pp. 258-268. 10.1021/tx00005a002.

Langley, D.R. and Thurston, D.E. (1987) A versatile and efficient synthesis of carbinolamine-containing pyrrolo[1,4]benzodiazepines via the cyclization of N-(2-aminobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetals: total synthesis of prothracarcin. Journal of Organic Chemistry, 52 (1). pp. 91-97. 10.1021/jo00377a016.

Buechter, D.D. and Thurston, D.E. (1987) Studies on the pyrrolizidine antitumor agent, clazamycin: interconversion of clazamycins A and B. Journal of Natural Products, 50 (3). pp. 360-367.

Richards, C.G. and Thurston, D.E. (1983) The diels-alder reaction of isoprene with 2-oxoindolin-3-ylidene derivatives. Tetrahedron, 39 (10). pp. 1817-1821. 10.1016/S0040-4020(01)88693-2.

Patent

Thurston, D. (2006) Alkyl 4-[4-(5-oxo-2,3,5,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)-butyrylamino]-1H -pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease. WO2007/039752.

School of Pharmacy (2004) Pyrrolobenzodiazepines. RJWL/LP6165765.

This list was generated on Tue Nov 25 09:57:33 2014 GMT.