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Group by: Item Type | Date | No Grouping
2012 | 2011 | 2010 | 2008 | 2006 | 2005 | 2004 | 2003 | 2000
Number of items: 27.

2012

Hancock, R., Bertrand, H.C., Tsujita, T., Naz, S., El-Bakry, A., Laoruchupong, J., Hayes, J.D. and Wells, G. (2012) Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction. Free Radical Biology and Medicine, 52 (2). pp. 444-451. 10.1016/j.freeradbiomed.2011.10.486.

Hancock, R., Bertrand, H.C., Tsujita, T., Naz, S., El-Bakry, A., Laoruchupong, J., Hayes, J.D. and Wells, G. (2012) Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction. Free Radical Biology and Medicine, 52 (2). pp. 444-451. 10.1016/j.freeradbiomed.2011.10.486.

2011

Konig, J., Wyllie, S., Wells, G., Stevens, M.F.G., Wyatt, P.G. and Fairlamb, A.H. (2011) Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism. Journal of Biological Chemistry, 286 (10). pp. 8523-8533. 10.1074/jbc.M110.214833.

Brucoli, F., Hawkins, R.M., James, C.H., Wells, G., Jenkins, T.C., Ellis, T., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. Bioorganic & Medicinal Chemistry Letters, 21 (12). pp. 3780-3783. 10.1016/j.bmcl.2011.04.054.

2010

Brucoli, F., Hawkins, R.M., Wells, G., Jenkins, T.C., Ellis, T., Kotecha, M., Hochhauser, D., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2010) 526 A potent PBD-heterocyclic polyamide conjugate targeting an ICB2 transcription factor binding site. European Journal of Cancer Supplements, 8 (7). p. 168. 10.1016/S1359-6349(10)72233-3.

Wells, G., Bradshaw, T.D., Diana, P., Seaton, A., Shi, D-F, Westwell, A.D. and Stevens, M.F.G. (2010) ChemInform Abstract: Antitumor Benzothiazoles. Part 10. The Synthesis and Antitumor Activity of Benzothiazole Substituted Quinol Derivatives. ChemInform, 31 (28). 10.1002/chin.200028129.

Wong, D.P.W., Wells, G. and Hagen, T. (2010) Heteroaromatic 4-arylquinols are novel inducers of Nuclear factor-erythroid 2-related factor 2 (Nrf2). European Journal of Pharmacology, 643 (2-3). pp. 188-194. 10.1016/j.ejphar.2010.06.040.

McCarroll, A.J., Matthews, C.S., Wells, G., Bradshaw, T.D. and Stevens, M.F.G. (2010) Synthesis of antitumour (1H-1,2,3-triazol-4-yl)-4-hydroxycyclohexa-2,5-dien-1-ones by copper-catalysed Huisgen cycloadditions. Organic & Biomolecular Chemistry, 8 (9). pp. 2078-2084.

2008

Aiello, S., Wells, G., Stone, E.L., Kadri, H., Bazzi, R., Bell, D.R., Stevens, M.F.G., Matthews, C.S., Bradshaw, T.D. and Westwell, A.D. (2008) Synthesis and Biological Properties of Benzothiazole, Benzoxazole, and Chromen-4-one Analogues of the Potent Antitumor Agent 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648)(1). Journal of Medicinal Chemistry, 51 (16). p. 5135. 10.1021/jm800418z.

Kotecha, M., Kluza, J., Wells, G., O'Hare, C.C., Forni, C., Mantovani, R., Howard, P.W., Morris, P., Thurston, D.E., Hartley, J.A. and Hochhauser, D. (2008) Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78. Molecular Cancer Therapeutics, 7 . pp. 1319-1328. 10.1158/1535-7163.MCT-07-0475.

Wells, G., Suggitt, M., Stephenson, M., Baig, M.A.H., Howard, P.W., Loadman, P.M., Hartley, J.A., Jenkins, T.J. and Thurston, D.E. (2008) Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization. Bioorganic and Medicinal Chemistry Letters, 18 . pp. 2147-2151. 10.1016/j.bmcl.2008.01.083 .

Duchesne, L., Wells, G., Fernig, D.G., Harris, S.A. and Levy, R. (2008) Supramolecular domains in mixed peptide self-assembled monolayers on gold nanoparticles. ChemBioChem, 9 (7). 10.1002/cbic.200800326.

2006

Shah, M.M., Wells, G., Bradshaw, T.D., Laughton, C.A., Stevens, M.F.G. and Westwell, A.D. (2006) Antitubercular properties of substituted hydroxycylohexadienones. Letters in Drug Design and Discovery, 3 (6). pp. 419-423. 10.2174/157018006777805486.

Stevens,M.F.G., Westwell,A.D.,Poole,T.D.and Wells,G. (2006) 2-Arylbenzothiazole derivatives. US 2006/063816.

Thurston, D. (2006) Alkyl 4-[4-(5-oxo-2,3,5,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)-butyrylamino]-1H -pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease. WO2007/039752.

Mortimer, C.G., Wells, G., Crochard, J.P., Stone, E., Bradshaw, T.D., Stevens, M.F.G. and Westwell, A.D. (2006) Antitumor benzothiazoles. 26.2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon and breast cancer cell lines. Journal of Medicinal Chemistry, 49 . pp. 179-185. 10.1021/jm050942k .

Lion, C.J., Matthews, C.S., Wells, G., Bradshaw, T.D., Stevens, M.F.G. and Westwell, A.D. (2006) Antitumor properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2, 5-dienones ('quinols'). Biorganic and Medicinal Chemistry Letters, 16 (19). pp. 5005-5008. 10.1016/j.bmcl.2006.07.072 .

Wells, G., Martin, C.R.H., Howard, P.W., Sands, Z.A., Laughton, C.A., Tiberghien, A.C., Woo, C.-K., Masterson, L., Stephenson, M.J., Hartley, J.A., Jenkins, T.C., Shnyder, S.D., Loadman, P.M., Waring, M.J. and Thurston, D.E. (2006) Design, synthesis and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates. Journal of Medicinal Chemistry, 49 (18). pp. 5442-5461. 10.1021/jm051199z .

2005

Bradshaw, T.D., Matthews, C.S., Cookson, J., Chew, E.-H., Shah, M.M., Bailey, K., Monks, A., Harris, E., Westwell, A.D., Wells, G., Laughton, C.A. and Stevens, M.F.G. (2005) Elucidation of thioredoxin as a molecular target for antitumor quinols. Cancer Research, 65 (5). pp. 3911-3919.

Howard,P.W.and Wells, G. (2005) Biaryl amino acids and their use in DNA binding oligomers. WO 2005/085177.

Berry, J.M., Bradshaw, T.D., Fitchner, I., Ruobo, R., Schwalbe, C.H., Wells, G., Chew, E-H., Stevens, M.F.G. and Westwell, A.D. (2005) Quinols as novel therapeutic agents. 2. 4(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2, 5-dien-1-ones and related agents as potent and selective antitumor agents. Journal of Medicinal Chemistry, 65 (2). pp. 639-644. 10.1021/jm040859h .

2004

School of Pharmacy, Stevens,M.F.G., Westwell,A.D.,Poole,T.D.,Wells,G.and Berry,J.M (2004) 4-(1-Sulfonyl)-1H-indol-2-yl)-4-hydroxycyclohexa-2,5-dienone compounds and analogues thereof as therapeutic agents. WO 2004/056361.

2003

School of Pharmacy, Poole,T.D.,Westwell,A.D.,Wells,G.and Stevens,M.F.G. (2003) 4-Arylquinols and analogues thereof as therapeutic agents. WO 2003/004479.

Wells, G., Berry, J.M., Bradshaw, T.D., Burger, A.M., Seaton, A., Wang, B., Westwell, A.D. and Stevens, M.F.G. (2003) 4-substituted-4-hydroxycyclohexa-2, 5-dien-1-ones with selective activities against colon and renal cancer cell lines. Journal of Medicinal Chemistry, 46 . pp. 532-541. 10.1021/jm020984y .

2000

Wells, G., Lowe, P.R. and Stevens, M.F.G. (2000) Antitumour benzothiazoles 13.(Diacetoxy)iodobenzene (DAIB) oxidation of 2-(4-hydroxy-3-methoxyphenyl)- benzothiazole and related compounds in the presence of dienophiles. Arkivoc, 1 . pp. 779-797.

Wells, G., Bradshaw, T.D., Diana, P., Seaton, A., Shi, D-F, Westwell, A.D. and Stevens, M.F.G. (2000) Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives. Bioorganic & Medicinal Chemistry Letters, 10 (5). pp. 513-515. 10.1016/S0960-894X(00)00027-5 .

Wells, G., Seaton, A. and Stevens, M.F.G. (2000) Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents. Journal of Medicinal Chemistry, 43 (8). pp. 1550-1562. 10.1021/jm990947f.

This list was generated on Sun Sep 21 03:03:37 2014 BST.