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Number of items: 27.

Hancock, R., Bertrand, H.C., Tsujita, T., Naz, S., El-Bakry, A., Laoruchupong, J., Hayes, J.D. and Wells, G. (2012) Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction. Free Radical Biology and Medicine, 52 (2). pp. 444-451. 10.1016/j.freeradbiomed.2011.10.486.

Hancock, R., Bertrand, H.C., Tsujita, T., Naz, S., El-Bakry, A., Laoruchupong, J., Hayes, J.D. and Wells, G. (2012) Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction. Free Radical Biology and Medicine, 52 (2). pp. 444-451. 10.1016/j.freeradbiomed.2011.10.486.

Konig, J., Wyllie, S., Wells, G., Stevens, M.F.G., Wyatt, P.G. and Fairlamb, A.H. (2011) Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism. Journal of Biological Chemistry, 286 (10). pp. 8523-8533. 10.1074/jbc.M110.214833.

Brucoli, F., Hawkins, R.M., James, C.H., Wells, G., Jenkins, T.C., Ellis, T., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2011) Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box. Bioorganic & Medicinal Chemistry Letters, 21 (12). pp. 3780-3783. 10.1016/j.bmcl.2011.04.054.

Brucoli, F., Hawkins, R.M., Wells, G., Jenkins, T.C., Ellis, T., Kotecha, M., Hochhauser, D., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2010) 526 A potent PBD-heterocyclic polyamide conjugate targeting an ICB2 transcription factor binding site. European Journal of Cancer Supplements, 8 (7). p. 168. 10.1016/S1359-6349(10)72233-3.

Wells, G., Bradshaw, T.D., Diana, P., Seaton, A., Shi, D-F, Westwell, A.D. and Stevens, M.F.G. (2010) ChemInform Abstract: Antitumor Benzothiazoles. Part 10. The Synthesis and Antitumor Activity of Benzothiazole Substituted Quinol Derivatives. ChemInform, 31 (28). 10.1002/chin.200028129.

Wong, D.P.W., Wells, G. and Hagen, T. (2010) Heteroaromatic 4-arylquinols are novel inducers of Nuclear factor-erythroid 2-related factor 2 (Nrf2). European Journal of Pharmacology, 643 (2-3). pp. 188-194. 10.1016/j.ejphar.2010.06.040.

McCarroll, A.J., Matthews, C.S., Wells, G., Bradshaw, T.D. and Stevens, M.F.G. (2010) Synthesis of antitumour (1H-1,2,3-triazol-4-yl)-4-hydroxycyclohexa-2,5-dien-1-ones by copper-catalysed Huisgen cycloadditions. Organic & Biomolecular Chemistry, 8 (9). pp. 2078-2084.

Aiello, S., Wells, G., Stone, E.L., Kadri, H., Bazzi, R., Bell, D.R., Stevens, M.F.G., Matthews, C.S., Bradshaw, T.D. and Westwell, A.D. (2008) Synthesis and Biological Properties of Benzothiazole, Benzoxazole, and Chromen-4-one Analogues of the Potent Antitumor Agent 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648)(1). Journal of Medicinal Chemistry, 51 (16). p. 5135. 10.1021/jm800418z.

Kotecha, M., Kluza, J., Wells, G., O'Hare, C.C., Forni, C., Mantovani, R., Howard, P.W., Morris, P., Thurston, D.E., Hartley, J.A. and Hochhauser, D. (2008) Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78. Molecular Cancer Therapeutics, 7 . pp. 1319-1328. 10.1158/1535-7163.MCT-07-0475.

Wells, G., Suggitt, M., Stephenson, M., Baig, M.A.H., Howard, P.W., Loadman, P.M., Hartley, J.A., Jenkins, T.J. and Thurston, D.E. (2008) Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization. Bioorganic and Medicinal Chemistry Letters, 18 . pp. 2147-2151. 10.1016/j.bmcl.2008.01.083 .

Duchesne, L., Wells, G., Fernig, D.G., Harris, S.A. and Levy, R. (2008) Supramolecular domains in mixed peptide self-assembled monolayers on gold nanoparticles. ChemBioChem, 9 (7). 10.1002/cbic.200800326.

Shah, M.M., Wells, G., Bradshaw, T.D., Laughton, C.A., Stevens, M.F.G. and Westwell, A.D. (2006) Antitubercular properties of substituted hydroxycylohexadienones. Letters in Drug Design and Discovery, 3 (6). pp. 419-423. 10.2174/157018006777805486.

Stevens,M.F.G., Westwell,A.D.,Poole,T.D.and Wells,G. (2006) 2-Arylbenzothiazole derivatives. US 2006/063816.

Thurston, D. (2006) Alkyl 4-[4-(5-oxo-2,3,5,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)-butyrylamino]-1H -pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease. WO2007/039752.

Mortimer, C.G., Wells, G., Crochard, J.P., Stone, E., Bradshaw, T.D., Stevens, M.F.G. and Westwell, A.D. (2006) Antitumor benzothiazoles. 26.2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon and breast cancer cell lines. Journal of Medicinal Chemistry, 49 . pp. 179-185. 10.1021/jm050942k .

Lion, C.J., Matthews, C.S., Wells, G., Bradshaw, T.D., Stevens, M.F.G. and Westwell, A.D. (2006) Antitumor properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2, 5-dienones ('quinols'). Biorganic and Medicinal Chemistry Letters, 16 (19). pp. 5005-5008. 10.1016/j.bmcl.2006.07.072 .

Wells, G., Martin, C.R.H., Howard, P.W., Sands, Z.A., Laughton, C.A., Tiberghien, A.C., Woo, C.-K., Masterson, L., Stephenson, M.J., Hartley, J.A., Jenkins, T.C., Shnyder, S.D., Loadman, P.M., Waring, M.J. and Thurston, D.E. (2006) Design, synthesis and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates. Journal of Medicinal Chemistry, 49 (18). pp. 5442-5461. 10.1021/jm051199z .

Bradshaw, T.D., Matthews, C.S., Cookson, J., Chew, E.-H., Shah, M.M., Bailey, K., Monks, A., Harris, E., Westwell, A.D., Wells, G., Laughton, C.A. and Stevens, M.F.G. (2005) Elucidation of thioredoxin as a molecular target for antitumor quinols. Cancer Research, 65 (5). pp. 3911-3919.

Howard,P.W.and Wells, G. (2005) Biaryl amino acids and their use in DNA binding oligomers. WO 2005/085177.

Berry, J.M., Bradshaw, T.D., Fitchner, I., Ruobo, R., Schwalbe, C.H., Wells, G., Chew, E-H., Stevens, M.F.G. and Westwell, A.D. (2005) Quinols as novel therapeutic agents. 2. 4(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2, 5-dien-1-ones and related agents as potent and selective antitumor agents. Journal of Medicinal Chemistry, 65 (2). pp. 639-644. 10.1021/jm040859h .

School of Pharmacy, Stevens,M.F.G., Westwell,A.D.,Poole,T.D.,Wells,G.and Berry,J.M (2004) 4-(1-Sulfonyl)-1H-indol-2-yl)-4-hydroxycyclohexa-2,5-dienone compounds and analogues thereof as therapeutic agents. WO 2004/056361.

School of Pharmacy, Poole,T.D.,Westwell,A.D.,Wells,G.and Stevens,M.F.G. (2003) 4-Arylquinols and analogues thereof as therapeutic agents. WO 2003/004479.

Wells, G., Berry, J.M., Bradshaw, T.D., Burger, A.M., Seaton, A., Wang, B., Westwell, A.D. and Stevens, M.F.G. (2003) 4-substituted-4-hydroxycyclohexa-2, 5-dien-1-ones with selective activities against colon and renal cancer cell lines. Journal of Medicinal Chemistry, 46 . pp. 532-541. 10.1021/jm020984y .

Wells, G., Lowe, P.R. and Stevens, M.F.G. (2000) Antitumour benzothiazoles 13.(Diacetoxy)iodobenzene (DAIB) oxidation of 2-(4-hydroxy-3-methoxyphenyl)- benzothiazole and related compounds in the presence of dienophiles. Arkivoc, 1 . pp. 779-797.

Wells, G., Bradshaw, T.D., Diana, P., Seaton, A., Shi, D-F, Westwell, A.D. and Stevens, M.F.G. (2000) Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives. Bioorganic & Medicinal Chemistry Letters, 10 (5). pp. 513-515. 10.1016/S0960-894X(00)00027-5 .

Wells, G., Seaton, A. and Stevens, M.F.G. (2000) Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents. Journal of Medicinal Chemistry, 43 (8). pp. 1550-1562. 10.1021/jm990947f.

This list was generated on Thu Apr 24 12:39:56 2014 BST.